2011
DOI: 10.3310/hta15450
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A 1-year follow-on study from a randomised, head-to-head, multicentre, open-label study of two pandemic influenza vaccines in children

Abstract: How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For Europ… Show more

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Cited by 2 publications
(3 citation statements)
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“…Pandemic influenza vaccines were suggested to provide seroprotective antibody levels against A/H1N1 influenza disease for up to 1 y after immunization in children. 13,15 This paper is the first to study and compare the immunogenicity of 2 different inactivated influenza vaccines for one year in healthy children. When we considered pure vaccine effects, there was no difference of immunity between split and subunit vaccines in the subjects without serological infections during a one year follow up.…”
Section: Discussionmentioning
confidence: 99%
“…Pandemic influenza vaccines were suggested to provide seroprotective antibody levels against A/H1N1 influenza disease for up to 1 y after immunization in children. 13,15 This paper is the first to study and compare the immunogenicity of 2 different inactivated influenza vaccines for one year in healthy children. When we considered pure vaccine effects, there was no difference of immunity between split and subunit vaccines in the subjects without serological infections during a one year follow up.…”
Section: Discussionmentioning
confidence: 99%
“…Antibody titres wane after vaccination. In a UK study, conducted in November and December 2010, 1 year after a two‐dose regimen of pandemic influenza vaccine, nearly all children who had received the AS03‐adjuvanted vaccine still had antibody titres above the putatively protective thresholds (microneutralisation titre ≥1:40, HI titre ≥1:32) . However, in these children, geometric mean titres for HI had declined to around 30% of the value seen 3 weeks after vaccination.…”
Section: Vaccine Immunogenicitymentioning
confidence: 99%
“…The 2010/2011 trivalent seasonal influenza vaccine, given to children who had received two doses of pandemic influenza vaccine 1 year earlier, produced a marked serological response to the H1N1 component of the vaccine, with a greater than 10‐fold rise in HI geometric mean titre …”
Section: Vaccine Immunogenicitymentioning
confidence: 99%