A 1-year prospective clinical trial of balafilcon a (purevision) silicone-hydrogel contact lenses used on a 30-day continuous wear schedule

Brennan, Noel A.; Coles, M.-L. Chantal; Comstock, Timothy L.; Levy, Brian

doi:10.1016/s0161-6420(02)01045-x

Cited by 124 publications

(61 citation statements)

References 13 publications

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“…Corneal microcysts were found in much greater numbers in wearers of other extended-wear disposable soft lenses. Limbal and bulbar injection were significantly less prominent with balafilcon A lenses used for 30 days of continuous wear than with standard hydrogel lenses used for 7 days of extended wear in a study by Brennan et al 27 Based on this information, it may be concluded that the high oxygen transmissibility of silicone hydrogel lenses is favorable for successful continuous lens wear without ocular irritation or discomfort. Our specimens did not show the presence of inflammatory cells that would be indicative of an inflammatory response.…”

Section: Discussionmentioning

confidence: 97%

Comparing Goblet Cell Densities in Patients Wearing Disposable Hydrogel Contact Lenses Versus Silicone Hydrogel Contact Lenses in an Extended-Wear Modality

Lievens

Connor

Murphy

2003

Eye & Contact Lens: Science & Clinical Practice

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Section: Discussionmentioning

confidence: 97%

Comparing Goblet Cell Densities in Patients Wearing Disposable Hydrogel Contact Lenses Versus Silicone Hydrogel Contact Lenses in an Extended-Wear Modality

Lievens

Connor

Murphy

2003

Eye & Contact Lens: Science & Clinical Practice

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“…In the period since these effects were discovered, several studies have confirmed the value of higher transmissibility lenses in eliminating limbal hyperaemia in the clinical setting [83][84][85][86][87][88][89][90][91][92][93].…”

Section: Vascular Changesmentioning

confidence: 99%

The significance of oxygen during contact lens wear

Papas

2014

Contact Lens and Anterior Eye

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“…Thus, they protect the cornea from the hypoxia caused changes. [11][12][13][14] Furthermore, Santos et al have proven that SiH contact lenses are generally less susceptible to microbial adhesion, in comparison to conventional hydrogels. This feature facilitates better lens resistance to bacteria.…”

Section: Discussionmentioning

confidence: 99%

A survey of corneal changes caused by daily wear silicone hydrogel contact lenses

Kettesy

Vardai

Berta

et al. 2015

J. Innov. Opt. Health Sci.

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Purpose: The examination of the e®ects of second generation lotra¯lcon B silicone hydrogel (SiH) lenses on the cornea when worn for three years of daily wear. Material and Methods: 55 healthy patients were divided into two groups: current hydrogel contact lens wearers re¯tted with lotra¯lcon B lenses (Group 1; 28 patients) and neophyte contact lens wearers (Group 2; 27 patients). Each patient's subjective eye comfort was measured with a self-administered questionnaire. The corneas were analyzed using contact specular microscope to measure corneal thickness and the endothelium before the SiH lenses were¯tted after four weeks, one month, six months, one year, two years, and three years of lens wear. Results: Subjective complaints of patients in Group 1 were reduced; however patients in Group 2 experienced discomfort during thē rst two to four weeks of use. In Group 1, objective examinations identi¯ed a decrease in endothelial cell density. In Group 2, the endothelial cell density increased slightly in the¯rst two years but decreased after three years. The results indicate that lotra¯lcon B slows down the deleterious e®ects of contact lenses. The coe±cient of variation signi¯cantly decreased after six months in Group 1 (0.47 vs 0.44; p ¼ 0:049), whereas, in Group 2, the hexagonal cells improved signi¯cantly after one month (27.78 vs 28.25; p ¼ 0:025). Conclusion: Based on the subjects involved and the period of time under examination, it can be concluded that high-Dk SiH lenses support the physiological metabolism and functions of the cornea by improving oxygen provision.

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A 1-year prospective clinical trial of balafilcon a (purevision) silicone-hydrogel contact lenses used on a 30-day continuous wear schedule

Cited by 124 publications

References 13 publications

Comparing Goblet Cell Densities in Patients Wearing Disposable Hydrogel Contact Lenses Versus Silicone Hydrogel Contact Lenses in an Extended-Wear Modality

Comparing Goblet Cell Densities in Patients Wearing Disposable Hydrogel Contact Lenses Versus Silicone Hydrogel Contact Lenses in an Extended-Wear Modality

The significance of oxygen during contact lens wear

A survey of corneal changes caused by daily wear silicone hydrogel contact lenses

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