A 10-Year Analysis of Chromosomes in Non-Invasive Papillary Carcinoma of the Bladder

Summers, Jack L.; Falor, William H.; Ward, Rose Marie

doi:10.1016/s0022-5347(17)54954-x

Cited by 60 publications

(14 citation statements)

References 3 publications

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“…46 There are few reports of PNA receptor distribution in the dog. PNA receptors have been previously described on the distal convoluted tubules and Bowman's capsule of the canine kidney,20 a finding confirmed in this study, and on the suprabasilar cells of stratified squamous epithelium in dogs and several other specie^,^^.^^ as also confirmed in the present report.…”

Section: Discussionmentioning

confidence: 99%

Peanut Agglutinin Lectin Immunohistochemical Staining of Normal and Neoplastic Canine Tissues

Haines

1993

Vet Pathol

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Abstract.Peanut lectin binding sites were demonstrated in normal canine tissues and in 114 canine tumors by avidin biotin complex immunohistochemical staining on unfixed cryostat tissue sections. Peanut agglutinin (PNA) receptors occurred in a variety of normal cells and tissues, including lymphoid follicle center cells; cortical thymocytes; basal cells and the stratum spinosum of stratified squamous epithelium; columnar epithelium of the gastrointestinal tract; parietal cells and chief cells of the stomach; some endothelial cells; myelin; chrondrocytes; spermatogenic cells; cells of the adrenal medulla; Bowman's capsule and the distal convoluted tubules of the kidney; prostatic, perianal and endometrial epithelium; and the extracellular matrix of connective tissues. Neoplastic cell staining was sporadic and was most often observed in benign or well-differentiated neoplastic tissues in which the corresponding normal cells also expressed PNA binding sites. However, PNA also bound to some tumor cells in which the analogous normal tissues were unstained, including cells of some fibrosarcomas, rhabdomyosarcomas, hemangiopericytomas and proliferating myoepithelial cells in mixed mammary tumors. Although PNA binding is complex and heterogeneous in canine tissues and does not appear to immunohistochemically detect a moiety associated with neoplastic transformation per se in the majority of canine tumors, the expression of PNA receptors may be associated with neoplastic changes in some mesenchymal cell populations.

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Section: Discussionmentioning

confidence: 99%

Peanut Agglutinin Lectin Immunohistochemical Staining of Normal and Neoplastic Canine Tissues

Haines

1993

Vet Pathol

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“…Should the patient be given an immediate cystectomy or should a more conservative approach be initially attempted? In patients who underwent transurethral resection (TUR) alone, reported survival rates ranged between 39 and 57% [5]. Adjuvant therapy (especially bacillus Calmette-Guérin (BCG) immunotherapy) is generally recommended.…”

Section: Introductionmentioning

confidence: 99%

Low-Dose BCG Instillations in the Treatment of Stage T1 Grade 3 Bladder Tumours: Recurrence, Progression and Success

Lebrét

Gaudez

Hervé³

et al. 1998

European Urology

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“…More than 90% of cells of normal human bladder epithelium were found to be diploid and no polyploidy was seen [5]. It was observed that invasive cancer tended to have a large chromosome number in comparison to the noninvasive tumors which were nearly diploid [1][2][3][4][5][6][7], As in previous reports [3,8] …”

Section: Discussionmentioning

confidence: 93%

“…Cytogenetic evaluation of the resected tumor may help to make this differentia tion possible. Tumor cell ploidy has been reported to correlate with the morphology of the tumor [2, 3, 6] and marker chromosomes have been related to the recur rence rate and prognosis [8]. Thus cytogenetic analyses have been used in recent years to attempt further eluci dation of the biological properties of tumors.…”

Section: Introductionmentioning

confidence: 99%

Chromosome Analysis in Patients with Bladder Tumor

Mićić

Mićić²,

Milašin³

1988

Urol Int

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Cytogenetic analysis was performed in 80 patients with bladder tumor. The mitotic activity in patients with tumor G₁, G₂ and G₃ degree of differentiation was not significantly different among them. Most of the patients with noninvasive tumor (G₁) had a diploid or nearly diploid chromosome number, but all patients with invasive (G₂ and G₃) tumor had polyploidy. Marker chromosomes were found in 14 patients and 9 of them developed recurrence very soon. There is a good correlation between the recurrence rate and numerical or structural chromosomal abnormalities. This study emphasizes the importance of the chromosome analysis in the evaluation of therapy and prognosis for patients with bladder tumors.

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A 10-Year Analysis of Chromosomes in Non-Invasive Papillary Carcinoma of the Bladder

Abstract: A 10-year evaluation of chromosomal analysis of bladder tumors is reported. Emphasis is placed on the presence of chromosomal markers and their importance as prognostic indicators in patients with papillary bladder tumors.

Cited by 60 publications

References 3 publications

Peanut Agglutinin Lectin Immunohistochemical Staining of Normal and Neoplastic Canine Tissues

Peanut Agglutinin Lectin Immunohistochemical Staining of Normal and Neoplastic Canine Tissues

Low-Dose BCG Instillations in the Treatment of Stage T1 Grade 3 Bladder Tumours: Recurrence, Progression and Success

Chromosome Analysis in Patients with Bladder Tumor

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