A 10-Year Follow-up of a Longitudinal Study of Gallstone Prevalence at Necropsy in South East England

Khan, Hamed; Harrison, Margo S.; Bassett, E. Eryl; Bates, Tom

doi:10.1007/s10620-008-0682-3

Cited by 24 publications

(23 citation statements)

References 37 publications

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“…determined that the incidence rate of gallstone in pregnant women was 5-12 % and stated that this ratio increased with the number of pregnancies [15,16]. In the current study, that the rate of pregnancy-based cholesterol stone was determined to be about three times higher is consistent with results in literature (Table 1) (p=0.278).…”

Section: Discussionsupporting

confidence: 91%

Evaluation of Factors Affecting the Type of Gallstone

2015

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The aim of this study is to determine the factors affecting the formation of the gallstone types of cholesterol and pigment stones. This descriptive and retrospective study comprised 164 patients who underwent cholecystectomy. Research data were obtained using a data collection form with 34 questions developed by the researchers based on the relevant literature. Statistical analysis of the data was made on SPSS 15.0 software using the percentage assessment method and chi-square test. Advanced statistical analysis of the data was performed using multivariate logistic regression. Cholesterol stone was found to form in individuals with anemia, those going through the menopause, and those consuming liquid oil and not undertaking exercise. The risk of pigment stone formation was found to be higher in the obese and those with liver disease and who do not consume milk. From the results of the study, it was determined that the dietary habits, chronic diseases, and lifestyle behaviors of individuals could be effective factors in the formation of cholesterol and/or pigment stone.

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Section: Discussionsupporting

confidence: 91%

Evaluation of Factors Affecting the Type of Gallstone

2015

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“…1 Acute cholecystitis (AC) is a common general surgical condition and represents significant morbidity associated with gallstone disease. 2 The recommended management for AC consists of antibiotics and early laparoscopic cholecystectomy (LC).…”

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confidence: 99%

Patient outcomes after treatment with percutaneous cholecystostomy for biliary sepsis

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Peter

Durham-Hall

et al. 2014

annals

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1 Bradford Teaching Hospitals NHS Foundation Trust, UK 2 Doncaster and Bassetlaw Hospitals NHS Foundation Trust, UK ABSTRACT INTRODUCTION Acute cholecystitis is among the most common general surgical presentations. There is a cohort of patients who develop systemic sepsis and complications of acute cholecystitis. These patients are often elderly and co-morbid. Conservative management with percutaneous cholecystostomy has been shown to be a safe and effective management option in the acute setting. However, there is currently no consensus for the further management of these patients. In particular, there is a paucity of data on readmission rates and subsequent operative or non-operative management. METHODS A retrospective study was carried out of patients treated with a percutaneous cholecystostomy for biliary sepsis over a three-year period in a UK teaching hospital. Outcome measures were subsequent operative or conservative management, conversion rates, operative complications and readmission rates. RESULTS Twenty-five patients had a percutaneous cholecystostomy for the treatment of acute biliary sepsis. The median follow-up duration was 35 months. Thirteen patients (52%) had operative treatment. In the operative group, 6/13 had a laparoscopic cholecystectomy, 2/13 had a planned open cholecystectomy, 2/13 had abandoned procedures and 3/13 had a converted procedure. Complications in the operative group included: postoperative mortality (1/13), common bile duct injury requiring drainage and endoscopic stenting (1/13) and one patient required readmission with recurrent pain. In the non-operative group, 5/12 patients were readmitted with biliary sepsis, 5/12 had no readmissions, 1/12 died in the community and 1/12 was readmitted with biliary colic. CONCLUSIONS Percutaneous cholecystostomy is a recognised treatment modality for elderly, co-morbid patients with biliary sepsis. Nevertheless, the readmission rate in this group is relatively high at 5/12 (42%). Patients who undergo subsequent operative management have a conversion rate of 3/13 (23%) and a significant complication rate of 2/13 (15%). The further management of patients having undergone percutaneous cholecystostomy requires careful consideration on an individual case basis. The P-POSSUM (Portsmouth Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity) may aid decision making.

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“…[37] MS components are related to GD, and BMI and increased age are also related to GD. [9] The increased prevalence of MS components was observed in patients undergoing cholecystectomy. [7] As GD and plaque formation have common risk factors, we investigated the relationship between these frequent diseases.…”

Section: Discussionmentioning

confidence: 99%

“…A 10-year follow-up study failed to find any relation between GD and CVD. [9] Another study mentioned the higher prevalence of MS components in patients undergoing cholecystectomy, but CVD was not increased in GD patients. [7] One study did not support any major association between ischemic heart disease and GD.…”

Section: Discussionmentioning

confidence: 99%

“…However, controversial results have been obtained in various studies regarding the association between GD and cardiovascular disorders. [789101112] To the best of our knowledge, no study has sought to evaluate the direct relationship between GD and aortic atheromatous plaque as a manifestation of atherosclerosis, to date. This study was designed to investigate whether there is an association between abdominopelvic atheromatous plaque and GD.…”

Section: Introductionmentioning

confidence: 99%

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The association between gallstone disease and plaque in the abdominopelvic arteries

et al. 2017

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Background:The aim of this study was to assess the atheromatous plaque, in the abdominopelvic arteries as a marker of cardiac risk in patients with or without gallstone disease (GD).Materials and Methods:A total of 136 patients were enrolled in this cross-sectional study. Forty-eight patients had GD and the remaining 88 patients did not. The presence or absence of gallstones was noted during abdominal ultrasonography while vascular risk factors such as plaque formation, intima-media thickness, plaque calcification, mural thrombus, stenosis, aneurysm, and inflammation were recorded during an abdominopelvic computed tomography scan. In addition, percentage of the abdominopelvic aorta surface covered by atheromatous plaque was calculated.Results:The mean age of patients with GD and without GD was 50.81 ± 16.20 and 50.40 ± 12.43, respectively. Patients with GD were more likely to have diabetes mellitus, a higher body mass index (BMI) (P < 0.001), and higher cholesterol (P < 0.01), and low-density lipoprotein-cholesterol (P < 0.02) levels. No significant differences were found between the groups regarding other atherosclerotic risk factors. Patients with GD had significantly higher rates of the vascular risk factors as intima-media thickness, plaque formation, calcification, aneurysm, mural thrombosis, stenosis, and inflammation in all abdominal arterial segments other than aneurysm in the femoral arteries. In addition, patients with GD had severe atheromatous plaques in the abdominal aorta, common iliac, external iliac, and common femoral artery (CFA). In patients with GD, parameters of age, BMI, and systolic and diastolic blood pressure were all correlated with the severity of the atheromatous plaque in abdominal aorta, common iliac, external iliac, and CFA.Conclusion:We demonstrated a direct relationship between GD and abdominopelvic atheromatous plaque, which is a marker for increased cardiovascular risk, for the first time in the literature. Patients with GD exhibit greater abdominopelvic atherosclerosis and therefore, have a higher risk of cardiovascular disease.

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A 10-Year Follow-up of a Longitudinal Study of Gallstone Prevalence at Necropsy in South East England

Cited by 24 publications

References 37 publications

Evaluation of Factors Affecting the Type of Gallstone

Evaluation of Factors Affecting the Type of Gallstone

Patient outcomes after treatment with percutaneous cholecystostomy for biliary sepsis

The association between gallstone disease and plaque in the abdominopelvic arteries

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