A 10-year observational study of Streptococcus dysgalactiae bacteraemia in adults: frequent occurrence among female intravenous drug users

Ruppen, Corinne; Rasmussen, Magnus; Casanova, Carlo; Sendi, Parham

doi:10.4414/smw.2017.14469

Cited by 11 publications

(6 citation statements)

References 16 publications

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“…In line with our findings, the stG62647 genotype appears to have gained a strong foothold in several geographic regions, accounting for 47% of the S. dysgalactiae isolates in Germany during 2012–2016 ( 15 ), 31% in Canada during 2012–2014 ( 13 ), and 26% in Switzerland during 2006–2015 ( 14 ). The rapid expansion of this genotype could be related to a lack of herd immunity in the population, but the emergence of a clone with enhanced virulence potential cannot be ruled out.…”

Section: Discussionsupporting

confidence: 89%

Streptococcus dysgalactiae Bloodstream Infections, Norway, 1999–2021

Oppegaard¹,

Glambek²,

Skutlaberg³

et al. 2023

Emerg. Infect. Dis.

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Streptococcus dysgalactiae increasingly is recognized as a pathogen of concern for human health. However, longitudinal surveillance data describing temporal trends of S. dysgalactiae are scarce. We retrospectively identified all β-hemolytic streptococcal bloodstream infections reported in Bergen, in western Norway, during 1999–2021. To explore S. dysgalactiae disease burden in a broader context, we mapped the incidence of all microbial species causing bloodstream infections during 2012–2021. We found S. dysgalactiae incidence rates substantially increased during the study period; by 2021, S. dysgalactiae was the fifth most common pathogen causing bloodstream infections in our region. We noted genotypic shifts and found that the rising trend was related in part to the introduction and expansion of the stG62647 emm -type. S. dysgalactiae is among the most common causes of bloodstream infections in western Norway, and increased surveillance and unambiguous species identification are needed to monitor the disease burden attributable to this pathogen.

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Section: Discussionsupporting

confidence: 89%

Streptococcus dysgalactiae Bloodstream Infections, Norway, 1999–2021

Oppegaard¹,

Glambek²,

Skutlaberg³

et al. 2023

Emerg. Infect. Dis.

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“…First mentioned in a multicenter study from Argentina in 2016, this emm type was already described as the most abundant in the analyzed patient cohort [48]. In 2017, a retrospective study confirmed the dominance of stG62647 also for invasive SDSE infections in Switzerland [49]. In the same year, an increase in stG62647 infections since 2013 was also described in Norway, combined with a comprehensive genome analysis approach to examine the molecular basis for the success of this particular emm type [50].…”

Section: Introductionmentioning

confidence: 90%

Epidemiological and Clinical Features of Streptococcus dysgalactiae ssp. equisimilis stG62647 and Other emm Types in Germany

et al. 2023

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(1) Background: Streptococcus dysgalactiae subspecies equisimilis (SDSE) is an important β-hemolytic pathogen historically described as mainly affecting animals. Studies epidemiologically assessing the pathogenicity in the human population in Germany are rare. (2) Methods: the present study combines national surveillance data from 2010 to 2022 with a single-center clinical study conducted from 2016 to 2022, focusing on emm type, Lancefield antigen, antimicrobial resistance, patient characteristics, disease severity, and clinical infection markers. (3) Results: The nationwide reported invasive SDSE infections suggest an increasing infection burden for the German population. One particular emm type, stG62647, increased over the study period, being the dominant type in both study cohorts, suggesting a mutation-driven outbreak of a virulent clone. The patient data show that men were more affected than women, although in the single-center cohort, this trend was reversed for patients with stG62647 SDSE. Men affected by stG62647 developed predominantly fascial infections, whereas women suffering from superficial and fascial non-stG62647 SDSE infections were significantly younger than other patients. Increasing age was a general risk factor for invasive SDSE infections. (4) Conclusions: further studies are needed to further elucidate the raised questions regarding outbreak origin, underlying molecular mechanisms as well as sex-dependent pathogen adaptation.

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“…Bacterial culture supernatants were prepared from Streptococcus pyogenes strains 19165 (ATCC, Manassas, VA, USA), 50362 (clinical isolate from a biopsy), Streptococcus dysgalactiae subspecies equisimilis 12394 (ATCC, Manassas, VA, USA), and 5804 (clinical isolate, septic arthritis) [ 31 ]. Clinical isolates were kindly provided by Parham Sendi and Lucy J. Hathaway (Institute for Infectious Diseases, University of Bern, Bern, Switzerland).…”

Section: Methodsmentioning

confidence: 99%

Engineered Liposomes Protect Immortalized Immune Cells from Cytolysins Secreted by Group A and Group G Streptococci

Besançon

Larpin

Babiychuk

et al. 2022

Cells

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The increasing antibiotic resistance of bacterial pathogens fosters the development of alternative, non-antibiotic treatments. Antivirulence therapy, which is neither bacteriostatic nor bactericidal, acts by depriving bacterial pathogens of their virulence factors. To establish a successful infection, many bacterial pathogens secrete exotoxins/cytolysins that perforate the host cell plasma membrane. Recently developed liposomal nanotraps, mimicking the outer layer of the targeted cell membranes, serve as decoys for exotoxins, thus diverting them from attacking host cells. In this study, we develop a liposomal nanotrap formulation that is capable of protecting immortalized immune cells from the whole palette of cytolysins secreted by Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis—important human pathogens that can cause life-threatening bacteremia. We show that the mixture of cholesterol-containing liposomes with liposomes composed exclusively of phospholipids is protective against the combined action of all streptococcal exotoxins. Our findings pave the way for further development of liposomal antivirulence therapy in order to provide more efficient treatment of bacterial infections, including those caused by antibiotic resistant pathogens.

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A 10-year observational study of Streptococcus dysgalactiae bacteraemia in adults: frequent occurrence among female intravenous drug users

Cited by 11 publications

References 16 publications

Streptococcus dysgalactiae Bloodstream Infections, Norway, 1999–2021

Streptococcus dysgalactiae Bloodstream Infections, Norway, 1999–2021

Epidemiological and Clinical Features of Streptococcus dysgalactiae ssp. equisimilis stG62647 and Other emm Types in Germany

Engineered Liposomes Protect Immortalized Immune Cells from Cytolysins Secreted by Group A and Group G Streptococci

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