“…In the Canadian study, nonspecific disorders or disorders other than mood disorders (that is, sleep, anxiety, and in some subjects, neurodevelopmental disorders) were antecedents to the onset of subsequent BD in high-risk children. 89 In the 10-year prospective follow-up study of the offspring of Amish parents with BD I, 87,90 prodromal symptoms indicating risk for BD included anxiety or somatic complaints, distractibility or role impairment in school, excitability, hyperalertness, and mood lability. As the children grew older, more classic bipolar symptoms became significant; these included talking loudly, excessive talking, high energy, problems with thinking and concentration, and problems with sleep (that is, decreased sleep, early awakening, and initial insomnia).…”