A 10-Year Retrospective Study of Inclusion Body Hepatitis in Meat-Type Chickens in Spain (2011–2021)

Bertran, Kateri; Blanco, Ángela; Antilles, Noelia; Nofrarías, Miquel; Valle, Rosa; Cobos, Alex; Ramis, Antonio; Biarnés, Mar; Majó, Natàlia

doi:10.3390/v13112170

Cited by 13 publications

(10 citation statements)

References 26 publications

(52 reference statements)

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“…HHS is clinically similar to IBH, but the mortality in HHS may reach 80% ( 4 , 22 , 23 ) and is characterized by poor development, apathy, prostration, ruffled feathers, and huddling behavior which are some of the clinical indications that may be observed in affected chickens ( 4 , 24 ). In addition, Bertran et al ( 25 ) mentioned that the economic losses in Spain was caused by vaccination in broiler breeders due to increasing IBH cases.…”

Section: A Brief Historymentioning

confidence: 99%

“…In addition, several reports of IBH and/or HHS were documented in Japan ( 31 ), Korea ( 32 ), India ( 33 ), Pakistan ( 34 ), Spain ( 25 ), Poland ( 35 ), Iran ( 36 ), Mexico ( 37 ), Brazil ( 38 ), Croatia ( 39 ), Australia ( 40 ), Greece ( 41 ), Iraq ( 42 ), Palastine ( 43 ), United Arab Emirates ( 44 ), Saudi Arabia ( 45 ), Morocco ( 46 ), and South Africa ( 47 ).…”

Section: Current Status Of Ibh And/or Hhs Associated Problemsmentioning

confidence: 99%

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Epidemiology, pathology, prevention, and control strategies of inclusion body hepatitis and hepatitis-hydropericardium syndrome in poultry: A comprehensive review

et al. 2022

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Infection with fowl adenoviruses (FAdVs) can result in a number of syndromes in the production of chicken, including inclusion body hepatitis (IBH), hepatitis-hydropericardium syndrome (HHS), and others, causing enormous economic losses around the globe. FAdVs are divided into 12 serotypes and five species (A–E; 1–8a and 8b−11). Most avian species are prone to infection due to the widespread distribution of FAdV strains. The genus aviadenovirus, which is a member of the adenoviridae family, is responsible for both IBH and HHS. The most popular types of transmission are mechanical, vertical, and horizontal. Hepatitis with basophilic intranuclear inclusion bodies distinguishes IBH, but the buildup of translucent or straw-colored fluid in the pericardial sac distinguishes HHS. IBH and HHS require a confirmatory diagnosis because their clinical symptoms and postmortem abnormalities are not unique to those conditions. Under a microscope, the presence of particular lesions and inclusion bodies may provide clues. Traditional virus isolation in avian tissue culture is more delicate than in avian embryonated eggs. Additionally, aviadenovirus may now be quickly and precisely detected using molecular diagnostic tools. Preventive techniques should rely on efficient biosecurity controls and immunize breeders prior to production in order to protect progeny. This current review gives a general overview of the current local and global scenario of IBH, and HHS brought on by FAdVs and covers both their issues and preventative vaccination methods.

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Section: A Brief Historymentioning

confidence: 99%

Section: Current Status Of Ibh And/or Hhs Associated Problemsmentioning

confidence: 99%

Epidemiology, pathology, prevention, and control strategies of inclusion body hepatitis and hepatitis-hydropericardium syndrome in poultry: A comprehensive review

et al. 2022

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“…FAdV-D and FAdV-E species together are frequently isolated from inclusion body hepatitis (IBH) cases. For example, a detailed study exhibited that FAdV-D serotype 11 is responsible for up to 33 per cent of the IBH that occurred in Spain in the last decades, while FAdV-E serotype 8a and 8b were 64.7% (Bertran et al, 2021). Recently, the presence of FAdV-D serotype 11 and FadV-E 8a and 8b has been documented in Turkey (Cizmecigil et al, 2020;Şahindokuyucu et al, 2020).…”

Section: Various Methods Have Been Proposed To Detectmentioning

confidence: 99%

Characterization of fowl aviadenovirus species in backyard flocks in Turkey

Kalın

Turan²,

Atasoy³

et al. 2022

J Hellenic Vet Med Soc

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Fowl aviadenovirus infections show a worldwide distribution in poultry at all ages and the incidence of the disease is increasing year after year. Most of the studies have been exhibited the situation of the disease in commercial chickens especially in broilers but there is not sufficient data to estimate in backyards. Totally 389 internal organ samples were collected from 56 flocks from suspicious backyard chickens at ages between 10-35 weeks. Samples were tested by PCR method and nucleotide sequences of hexon genes were used for phylogenetic analyses and comparing with other FAdV sequences submitted to GenBank. Of the 389 samples, 23.9% were found FAdV positive and 30.4% (17/56) of the ﬂocks sampled in the study were infected. This is the first study that was carried out in backyards and two species (D and C) and four serotypes (FAdV-8a, FAdV-3, FAdV-4, and FAdV-10) have been discovered for the first time in Turkey. To understand the epidemiology of FAdV in Turkey and to get enough information about species and serotypes further large scale national studies should be carried out to determine the severity of FAdV infections and to plan control strategies.

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“…Earlier workers (Alvarado et al, 2007;Chitradevi et al, 2018;Bertran et al, 2021) were able to use different sets of primers designed to amplify the Hexon gene at different sites.…”

Section: Molecular Detectionmentioning

confidence: 99%

Pathogenicity Assessment and Vaccine Efficacy of Fowl Adenovirus Serotype 4 and 11 Responsible for Inclusion Body Hepatitis Hydropericardium Syndrome in Broilers

Joshi¹,

Dave²,

Joddha³

et al. 2022

ijvsbt

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This study aimed to assess the pathogenicity and vaccine efficacy of fowl adenovirus serotypes 4 and 11, causing inclusion body hepatitis hydropericardium syndrome in broilers. The study was carried out on 144-day-old Cobb broiler chicks divided into six experimental groups, each of 24 birds. Group, I birds served as a control without any vaccine or viral challenge, while birds of Group II were vaccinated with commercial vaccine on 6 th day. Group III and IV birds were non-vaccinated and challenged with 107 TCID50 of FAdV serotype 4 and 11, respectively, on the 27 th day. In contrast, Group V and VI birds were vaccinated on the 6 th day and challenged with 107 TCID50 of FAdV serotype 4 and 11 on the 27 th day. The challenge of FAdV serotype 4 led to 66.66% mortality, and serotype 11 produced 5.00% mortality in the experimental groups. The challenge of the virus led to the production of clinical signs such as depression, huddling, reduced feed intake, reluctance to move, and terminal gasping before death. Characteristic gross lesions of IBH-HPS were observed in birds that died after the challenge of serotypes 4 and 11 of FAdV. The liver was enlarged with focal areas of necrosis, subcapsular hemorrhages, and mild fatty changes. The heart was flabby, congested, and showed hydropericardium with an accumulation of clear watery to a yellow jelly-like fluid in the pericardial sac. The kidneys were enlarged and hemorrhagic. On microscopic examination, the liver showed multifocal areas of necrosis with infiltration of mononuclear cells, mild fatty changes and large basophilic intranuclear inclusion bodies. The birds that died after the challenge of the virus were positive for the presence of FAdV upon PCR. The vaccine efficacy study indicated that the vaccine provided satisfactory protection against Fowl Adenovirus challenge in experimental groups V and VI.

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A 10-Year Retrospective Study of Inclusion Body Hepatitis in Meat-Type Chickens in Spain (2011–2021)

Cited by 13 publications

References 26 publications

Epidemiology, pathology, prevention, and control strategies of inclusion body hepatitis and hepatitis-hydropericardium syndrome in poultry: A comprehensive review

Epidemiology, pathology, prevention, and control strategies of inclusion body hepatitis and hepatitis-hydropericardium syndrome in poultry: A comprehensive review

Characterization of fowl aviadenovirus species in backyard flocks in Turkey

Pathogenicity Assessment and Vaccine Efficacy of Fowl Adenovirus Serotype 4 and 11 Responsible for Inclusion Body Hepatitis Hydropericardium Syndrome in Broilers

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