A 12-month prospective clinical trial of comfilcon A silicone-hydrogel contact lenses worn on a 30-day continuous wear basis

Have Silicone Hydrogel Lenses Eliminated Hypoxia?

“…30 When a group of patients were refitted with continuous wear silicone hydrogels after 12 months of low Dk extended wear, the number of microcysts increased initially over the first weeks and then reduced and returned to the levels seen with spectacle wearers over the next three months. 16 Brennan et al 66 conducted a 12-month prospective clinical trial involving 45 patients wearing 3 silicone hydrogel materials on a continuous wear basis. A similar response is observed with cessation of low Dk extended lens wear.…”

“…Percentage of patients exhibiting microcysts on at least 1 occasion during a 12-month prospective study with 3 silicone hydrogel lenses worn on a continuous wear basis (adapted from Brennan et al66 ).…”

Short-Term Clinical Comparison of Two Dual-Disinfection Multipurpose Disinfecting Solutions

“…[31][32][33] Although increased limbal hyperemia is often associated with hypoxia, [34][35][36][37][38] it can also be influenced by the LCS 17 or be caused by mechanical stimulation of the contact lens edge. [31][32][33] Although increased limbal hyperemia is often associated with hypoxia, [34][35][36][37][38] it can also be influenced by the LCS 17 or be caused by mechanical stimulation of the contact lens edge.…”

The role of multi-purpose solutions in prevention and removal of lipid depositions on contact lenses

“…As for the other lenses, comfilcon A lenses are inherently wettable, reportedly having more hydrophilic units in its chemistry and thus requiring no surface treatment [24]. Balafilcon A lenses are plasma oxidized, which purportedly converts the TRIS structure on the surface into islands of hydrophilic silicate [25][26][27].…”