A 12-Year Retrospective Analysis of Blood Culture Isolates in the Intensive Care Unit of a Tertiary Hospital in China

Peng, Zhenli; Wang, Yanxin; Jia, Lijuan; Yao, Jianquan; Li, Xiang

doi:10.7754/clin.lab.2022.220223

Cited by 1 publication

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“…Recently, two studies from China were published indicating that among cases of bloodstream infection, 60–70% are caused by gram-negative bacteria, with E. coli being the predominant species that have been isolated. 11 , 12 A MEDLINE database search with keywords such as “bloodstream infection”, “urinary tract infection”, “antimicrobial susceptibility”, and “China” yielded around 286 studies, but none of them focused on the trends of E. coli in these infections. A multicentre study revealed that E. coli infections with increased antimicrobial resistance occurred in China according to the China Antimicrobial Surveillance Network (CHINET- http://www.chinets.com,2016 ).…”

Section: Introductionmentioning

confidence: 99%

“…However, resistance to these antibiotics has been increasing over time. 11 The reason for the high prevalence of E. coli bloodstream infections, and urinary tract infections, as well as the development of antibiotic resistance, may be linked to increased antibiotic usage in the population, individual hospitals and primary care. 13 Our hospital adopted a new antibiotic therapy policy in 2015 14 while monitoring the changes in antibiotic-resistant bacteria to be better equipped to prevent disease.…”

Section: Introductionmentioning

confidence: 99%

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Trends in Antibiotic Resistance Patterns and Burden of Escherichia Coli Infections in Young Children: A Retrospective Cross-Sectional Study in Shenzhen, China from 2014–2018

Patil,

Chen,

Chen

et al. 2023

IDR

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Purpose The emergence of multi-drug resistant ESBL-producing E. coli poses a global health problem. In this study, we aimed to investigate the prevalence of E. coli infections and their antibiotic susceptibility profiles in paediatric clinical cases in Shenzhen, China from Jan 1, 2014, to Jan 30, 2019, while also determining temporal trends, identifying ESBL-producing strains, and recommending potential empirical antibiotic therapy options. Methods We isolated a total of 4148 E. coli from different specimens from a single paediatric healthcare centre. Additionally, we obtained relevant demographic data from the hospital’s electronic health records. Subsequently, we performed antimicrobial susceptibility testing for 8 classes of antibiotics and assessed ESBL production. Results Out of the 4148 isolates, 2645 were from males. The highest burden of E. coli was observed in the age group of 0–1 years, which gradually declined over the five-year study period. Antimicrobial susceptibility results indicated that 82% of E. coli isolates were highly resistant to ampicillin, followed by 52.36% resistant to cefazolin and 47.46% resistant to trimethoprim/sulfamethoxazole. Notably, a high prevalence of ESBL production (49.54%) was observed among the E. coli isolates, with 60% of them displaying a multi-drug resistance phenotype. However, it is worth mentioning that a majority of the isolates remained susceptible to ertapenem and imipenem. Our findings also highlighted a decrease in E. coli infections in Shenzhen, primarily among hospitalized patients in the 0–1 year age group. However, this decline was accompanied by a considerably high rate of ESBL production and increasing resistance to multiple antibiotics. Conclusion Our study underscores the urgent need for effective strategies to combat multi-drug resistant ESBL-producing E. coli Infections.

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Section: Introductionmentioning

confidence: 99%