A 15 month controlled study of the effects of amodiaquin (camoquin) in rheumatoid arthritis

Bepler, C. Robert; Baier, H. N.; McCracken, Stewart; Rentschler, Curtis L.; Rogers, Fred B.; Lansbury, John

doi:10.1002/1529-0131(195910)2:5<403::aid-art1780020505>3.0.co;2-i

Cited by 17 publications

(4 citation statements)

References 7 publications

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“…Chloroquineresistant malaria is increasingly common in east Africa (Brandling-Bennett et al, 1988), and has been documented in Zambia and Nigeria. However, (Booth et al, 1967;Glick, 1957;Kennedy, 1955;Lind et al, 1973;Love et al, 1953;Perry et al, 1962) and hepatitis (Bepler et al, 1959;Pomeroy et al, 1959) have appeared since the drug's first use. In 1986 several reports of serious reactions to prophylactic AQ (Carr, 1986;Hatton et al, 1986;Neftel et al, 1986;Rhodes et al, 1986) caused the principal manufacturer to withdraw the compound from preventative use, and to date there have been no reports of serious toxicity to AQ in malaria patients.…”

Section: Discussionmentioning

confidence: 99%

The disposition of amodiaquine in Zambians and Nigerians with malaria.

Winstanley

Simooya

Kofiekue

et al. 1990

Brit J Clinical Pharma

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1 Oral amodiaquine (AQ) has been used to treat patients with symptomatic malaria in Zambia (n = 14) and Nigeria (n = 5). Clinical cure was obtained in all patients and no serious adverse drug reactions were seen. 2 As in healthy subjects, AQ achieved low plasma concentrations. Plasma concentration vs time profiles of desethylamodiaquine (AQm) from the present study did not differ from those obtained from healthy subjects. 3 In contrast to previous results from healthy subjects, the mean ratio of red cell (RBC) plasma AQm concentration in the present study was 0.80 : 1 at the start of the study and rose in a linear manner (r = 0.873; P < 0.01) to 3.04: 1 by the end (n = 10; P < 0.01). The final mean value was similar to that seen in healthy subjects. 4 These data show that there are differences in the disposition of orally administered AQ between healthy subjects and patients with clinical malaria. The relevance of this observation to the frequency of adverse reactions to AQ in these two groups is not established.

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Section: Discussionmentioning

confidence: 99%

The disposition of amodiaquine in Zambians and Nigerians with malaria.

Winstanley

Simooya

Kofiekue

et al. 1990

Brit J Clinical Pharma

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“…The corticosteroids failed to antagonize bradykinin and so did chloroquine and amodiaquine, which are reported to be useful in rheumatoid arthritis (Haydu, 1953;Freedman, 1956;Pomeroy, Warren, Mills, and Clark, 1959;Bepler, Baier, McCracken, Rentschler, Rogers, and Lansbury, 1959;Kersley and Palin, 1959). Chen and Weston (1960) …”

Section: Discussionmentioning

confidence: 99%

Analgesic Antipyretic Drugs as Antagonists of Bradykinin

Collier¹,

Shorley²

1960

British Journal of Pharmacology and Chemotherapy

100

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The antagonism between analgesic antipyretic drugs and bradykinin was examined quantitatively, using the bronchoconstrictor response of guinea-pigs in vivo. The dose of bradykinin required to overcome antagonism by calcium acetylsalicylate increased with the dose of acetylsalicylate given, the ratio being roughly constant. Fifty times the quantity of acetylsalicylate which just antagonized bradykinin did not modify bronchoconstriction due to small doses of histamine, 5-hydroxytryptamine, or acetylcholine. A method of measuring the potency of this anti-bradykinin action was developed. Acetylsalicylic acid, phenylbutazone, amidopyrine, and phenazone had a high potency; paracetamol, cinchophen, sodium salicylate, and acetanilide had a moderate potency; and phenacetin, salicylamide, and 4-hydroxyisophthalic acid had little or none. Cortisone, hydrocortisone, aldosterone, amodiaquine, and morphine were ineffective o)r their action was non-specific. In sensitized guinea-pigs, an injection of antigen caused bronchospasm. This response was greatly lessened by pretreatment with mepyramine, but was not affected by calcium acetylsalicylate, lysergic acid diethylamide, or atropine. Acetylsalicylic acid, phenylbutazone, and amidopyrine did not specifically antagonize the action of bradykinin on the capillaries of guinea-pig skin in vivo, on guinea-pig ileum in vitro or on rat duodenum in vitro.Collier, Holgate, Schachter, and Shorley (1959Shorley ( , 1960 found that bradykinin causes bronchoconstriction in the guinea-pig, that small doses of acetylsalicylic acid, phenylbutazone and amidopyrine suppress this response without affecting those to histamine or 5-hydroxytryptamine, and that increasing the dose of bradykinin overcomes this suppression. Since the relationship between these analgesic and antipyretic drugs and bradykinin in its bronchoconstrictor action shows the main features of pharmacological antagonism, we thought it worth while to study this relationship quantitatively, to measure the potency of antagonism and to explore how effective were other antipyretic, analgesic, anti-inflammatory and anti-rheumatic drugs. Since bradykinin might take part in anaphylactic bronchospasm, we investigated whether pre-treatment with acetylsalicylate lessened the intensity of this spasm. We examined also whether the antagonists of bradykinin in its bronchoconstrictor action likewise antagonized some of its other actions. METHODS Materials.-Bradykinin was prepared by the action of crystalline trypsin on heated beef serum globulin and was purified chromatographically. The potencies of preparations, standardized against pure bradykinin obtained with trypsin (Elliott, Lewis, and Horton, 1960), ranged from 0.6 to 16 pxg. pure bradykinin/mg.Substances tested in acute experiments as antagonists of bradykinin are given in Table III, which shows the salts used. Histamine acid phosphate, 5-hydroxytryptamine creatinine sulphate and acetylcholine chloride were also employed as bronchoconstrictor agents and mepyramine maleate, lysergic acid di...

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“…to chloroquine has been used in the treatment and prevention of malaria, as well as in the treatment of diseases such as rheumatoid arthritis and lupus erythematosus [18,19]. It was encouraged for use at the time only in chloroquine resistant areas [20] largely due to its propensity to induce agranulocytosis in people when administered for malaria prophylaxis.…”

Section: Introductionmentioning

confidence: 99%

Oral Amodiaquine, Artesunate and Artesunate Amodiaquine Combination Affects Open Field Behaviors and Spatial Memory in Healthy Swiss Mice

Onaolapo¹,

Onaolapo²,

Awe³

et al. 2013

JBBS

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Effects of amodiaquine, artesunate and artesunate amodiaquine combination on open field novelty-induced behaviors and spatial memory in healthy mice were studied. Forty mice were used in the open field and fifty each in the radial arm maze and Y maze; mice were assigned into four or five groups of ten each, Group A served as control (distilled water), Groups B, C and D received artesunate (4 mg/kg), amodiaquine (10 mg/kg) and artesunate-amodiaquine combination (4 mg/kg and10 mg/kg) respectively, while Group E animals (for the cognition tests) were given scopolamine (2 mg/kg). Drugs and vehicle were administered orally for three days. Results were analysed by one way analysis of variance followed by a posthoc test. Results showed that artesunate and amodiaquine either in combination or administered singly caused a significant increase in open field novelty-induced horizontal locomotion and rearing. Grooming in the open field showed increments in the artesunate alone and artesunate amodiaquine groups while significant reductions in spatial memory were also seen in the cognition models used.

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A 15 month controlled study of the effects of amodiaquin (camoquin) in rheumatoid arthritis

Cited by 17 publications

References 7 publications

The disposition of amodiaquine in Zambians and Nigerians with malaria.

The disposition of amodiaquine in Zambians and Nigerians with malaria.

Analgesic Antipyretic Drugs as Antagonists of Bradykinin

Oral Amodiaquine, Artesunate and Artesunate Amodiaquine Combination Affects Open Field Behaviors and Spatial Memory in Healthy Swiss Mice

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