A 15 years study of the causes of death among elderly hypertensive patients in a hospital-based sample of China

Cui, Hua; Hu, Yixin; Hong, Changming; Hu, Guoliang; Lyu, Fan

doi:10.1016/j.archger.2012.07.008

Cited by 4 publications

(4 citation statements)

References 16 publications

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“…Especially since the outbreak of COVID-19 in 2020, China's serious population aging problem has been aggravated [31,32]. The health problems and mortality risk of older adults have posed a great challenge to the promotion of the "Healthy China Strategy" [10,33]. The health of older adults is not only related to the quality of life of the older adults themselves and their families but also directly related to the burden of care for the whole society and the issue of sustainable development.…”

Section: Discussionmentioning

confidence: 99%

Research on Mortality Risk of Chinese Older Adults from the Perspective of Social Health

2022

Sustainability

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In response to the increasing aging problem that China is facing, this study aimed to investigate the impact of social health on the mortality risk of the Chinese older adult population. In this paper, we used the data from “The Chinese Longitudinal Health Longevity Survey (CLHLS)-Longitudinal Data (2008–2018)” and applied the Cox proportional hazard model to investigate the effects of three dimensions of social health on the risk of death among older adults in China. The study found that: (1) The three dimensions of social health have a positive effect on the mortality risk of older adults. (2) Among those three dimensions, social activities had the most significant effect on older adults. The effect of social support and social network on the mortality risk of older adults are basically similar. Moreover, social activity, social support, and the social network had no significant effect on the young-old’s mortality risk. (3) In order to address the problem of data censoring, the Cox proportional hazard model can be used, whereas demographic characteristics, health status, and health behavior components are selective to society. This study enriches social health research in China and promotes the development of social health research from theory to practice. Moreover, it has obvious advantages in terms of economics and feasibility for achieving mortality risk reduction through improving the social health of older adults and building a healthy aging society.

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Section: Discussionmentioning

confidence: 99%

Research on Mortality Risk of Chinese Older Adults from the Perspective of Social Health

2022

Sustainability

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“…As doenças cardiovasculares são responsáveis por 20% dos óbitos em indivíduos com mais de 30 anos no Brasil, seguido por neoplasias, doenças respiratórias e causas externas (2) . Segundo pesquisas que acompanharam hipertensos por um período de até 15 anos, entre 45%(13) e 60% (14) dos óbitos foram associados às doenças cardiovasculares, como a doença da artéria coronária (13,15) e insuficiência cardíaca (15) . A literatura também ressalta fatores como a obesidade, diabetes mellitus, dislipidemia (2,15) , doenças cerebrovasculares e insuficiência renal (13) , por exemplo, favorecem o aumento do risco de morte nestes indivíduos.…”

Section: Discussionunclassified

“…Ressalta-se ainda que as infecções, como a pneumonia e a sepse, são responsáveis por vários óbitos na cardiopatia hipertensiva. Estudos apontam que entre idosos hipertensos e com insuficiência cardíaca prévia, a proporção de óbitos por infecções pode alcançar 37% (13,16) . Recente revisão de literatura (17) salienta ainda que a presença da doença cardíaca crônica favorece o aumento em até 3,3 vezes da pneumonia comunitária, e até 9,9 vezes da doença pneumocócica invasiva de acordo com idade e outros fatores associados como diabetes mellitus, tabagismo, bronquite crônica e asma, confirmando os resultados encontrados neste presente estudo.…”

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Correlação entre cardiopatias hipertensivas e aterosclerose na artéria aorta

et al. 2017

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A hipertensão arterial sistêmica é uma doença multifatorial, comportando-se como fator desencadeador das doenças cardiovasculares e da aterosclerose. O objetivo foi descrever a associação de idade, gênero, cor da pele e o grau de aterosclerose na artéria aorta na cardiopatia hipertensiva em indivíduos autopsiados. Foram avaliados 34 seguimentos de artérias aortas abdominais de indivíduos autopsiados com cardiopatia hipertensiva (20) e sem cardiopatia hipertensiva (14). A idade, gênero, cor da pele e causa de morte foram coletadas do laudo de autopsia, a quantificação da intensidade de aterosclerose e o grau de aterosclerose através de escala padronizada. Neste estudo, a causa de morte e a intensidade da aterosclerose apresentaram associação significativa com a cardiopatia hipertensiva; houve prevalência de placas de ateroma de maior extensão entre os indivíduos com esta entidade. Desse modo, a aterosclerose deve ser investigada em indivíduos com cardiopatia hipertensiva visando prevenir graves repercussões, que podem culminar com o óbito.

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“…Hypertension is a key chronic disease and considered to be a major public health issue and the most common risk factor for myocardial infarction, heart failure, renal failure and even death throughout the world (Cui, Hu, Hong, Hu, & Fan, ). There are a variety of potential factors that result in hypertension including disease (Sarafidis & Bakris, ), smoking, alcohol consumption, physical activity level, high cholesterol and diabetes (Faselis et al, ; Li et al, ; Terry, Glynn, Buring, & Sesso, ).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and tissue distribution study of clevidipine and its primary metabolite H152/81 in rats

Zhao

Yang

et al. 2017

Biomedical Chromatography

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This present study was designed to investigate the pharmacokinetic profiles and tissue distribution characteristics of clevidipine and its primary metabolite H152/81 in rats following a single intravenous administration of clevidipine butyrate injectable emulsion. For this study, a sensitive and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was established and validated for the simultaneous quantitation of clevidipine and H152/81 in rat whole blood and various tissues. A Hedera ODS-2 column with two gradient elution programs was employed for the troubleshooting of matrix effect on the detection of analytes among different biological samples. The experimental data showed that clevidipine represented quick elimination from blood with a half-life of about 4.3 min and rapid distribution in all of the investigated tissues after administration; the highest concentration of clevidipine was found in the heart whereas the lowest concentration was detected in the liver. In addition, clevidipine was almost undetectable in most tissues except for heart and brain at 90 min post-dosing, suggesting that there was no apparent long-term accumulation in rat tissues. For H152/81, the peak concentration of 3714 ± 319 ng/mL occurred at 0.129 ± 0.048 h, the half-life was 10.08 ± 1.45 h and area under the concentration-time curve was 42091 ± 3812 ng h/mL after drug administration. In addition, H152/81 was found at significant concentration levels in all tissues, in descending order of lung, kidney, heart, liver, spleen and brain at each time point. The results of current study offer useful clues for better understanding the distribution and metabolism of clevidipine butyrate injectable emulsion in vivo.

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A 15 years study of the causes of death among elderly hypertensive patients in a hospital-based sample of China

Cited by 4 publications

References 16 publications

Research on Mortality Risk of Chinese Older Adults from the Perspective of Social Health

Research on Mortality Risk of Chinese Older Adults from the Perspective of Social Health

Correlação entre cardiopatias hipertensivas e aterosclerose na artéria aorta

Pharmacokinetics and tissue distribution study of clevidipine and its primary metabolite H152/81 in rats

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