A 19 μW, 50 kS/s, 0.008-400 V/s Cyclic Voltammetry Readout Interface With a Current Feedback Loop and On-Chip Pattern Generation

Lu, Shao-Yung; Liao, Yu-Te

doi:10.1109/tbcas.2021.3062377

Cited by 14 publications

(1 citation statement)

References 27 publications

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“…Although it is possible to integrate a few 150 pF capacitors using CMOS technology, it is challenging to integrate 100s of amplifiers. Current division or current subtraction can be used to decrease the required capacitance [21][22][23]; however, they come with a cost of power, area, or noise performance. An analog front-end with analog background subtraction was able to achieve high bandwidth (5 kHz) and low noise level (26.5 pARMS), however, the analog front-end size was relatively larger (0.256 mm 2 ) compared to other works that can achieve similar dynamic range [23].…”

Section: Introductionmentioning

confidence: 99%

A 128-ch Area-Efficient Neurochemical-Sensing Front-End for FSCV Recordings of Dopamine

White,

Darroudi,

Park

et al. 2024

IEEE Sensors J.

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Neurochemical recordings rely on electrochemical reactions of electroactive neurotransmitters such as dopamine, serotonin, and norepinephrine. This electrochemical technique allows for highly sensitive monitoring of neurotransmitters in the brain. Traditionally, single-channel carbon-fiber microelectrode recordings have been considered the gold standard method. However, an alternative approach involves the use of a microelectrode array, which enables high spatiotemporal resolution imaging of electroactive neurotransmitters. To enable neurochemical imaging using a microelectrode array, the development of a high-density current-sensing microchip is necessary. Here, a neurochemical microchip is introduced, featuring a 128-channel current sensing front-end capable of supporting 128 parallel neurochemical measurements. The designed amplifier array employs a highly scalable resistive feedback transimpedance amplifier design. This design allows for a large neurochemical dynamic range of ±5µA with a noise performance as low as 0.22nARMS. With the integration of this microchip, in vivo neurochemical imaging of dopamine can be achieved with high spatiotemporal resolution.

show abstract

Section: Introductionmentioning

confidence: 99%

A 128-ch Area-Efficient Neurochemical-Sensing Front-End for FSCV Recordings of Dopamine

White,

Darroudi,

Park

et al. 2024

IEEE Sensors J.

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show abstract

A 128-ch area-efficient neurochemical-sensing front-end for FSCV recordings of dopamine

White

Darroudi

Park

et al. 2023

Preprint

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Neurochemical recordings rely on electrochemical reactions of electroactive neurotransmitters such as dopamine, serotonin, and norepinephrine. This electrochemical technique allows for highly sensitive monitoring of neurotransmitters in the brain. Traditionally, single-channel carbon-fiber microelectrode recordings have been considered the gold standard method. However, an alternative approach involves the use of a microelectrode array, which enables high spatiotemporal resolution imaging of electroactive neurotransmitters. To enable neurochemical imaging using a microelectrode array, the development of a high-density current-sensing microchip is necessary. Here, a neurochemical microchip is introduced, featuring a 128-channel current sensing front-end capable of supporting 128 parallel neurochemical measurements. The designed amplifier array employs a highly scalable resistive feedback transimpedance amplifier design. This design allows for a large neurochemical dynamic range of 10uA with a noise performance as low as 0.22nARMS. With the integration of this microchip, in vivo neurochemical imaging of dopamine can be achieved with high spatiotemporal resolution.

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Body-Heat Powered Biosensor Readout using Current-mode Relaxation Oscillators

Chou

Cook

et al. 2022

2022 IEEE Biomedical Circuits and Systems Conference (BioCAS)

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A 19 μW, 50 kS/s, 0.008-400 V/s Cyclic Voltammetry Readout Interface With a Current Feedback Loop and On-Chip Pattern Generation

Cited by 14 publications

References 27 publications

A 128-ch Area-Efficient Neurochemical-Sensing Front-End for FSCV Recordings of Dopamine

A 128-ch Area-Efficient Neurochemical-Sensing Front-End for FSCV Recordings of Dopamine

A 128-ch area-efficient neurochemical-sensing front-end for FSCV recordings of dopamine

Body-Heat Powered Biosensor Readout using Current-mode Relaxation Oscillators

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