A 2-year step-down withdrawal from inhaled corticosteroids in asthmatic children receiving immunotherapy

He, Chun-Hui; Li, Xing; Jing, Lin; Xiao, Qiang; Yu, Jialu; Liu, Ying-Fen; Jiang, Wenhui; Chen, Chen; Deng, Li; Zhou, Jie

doi:10.1007/s12519-017-0065-y

Cited by 2 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have demonstrated significant dose- 21,22 and duration-dependent 23 and reversible [24][25][26][27] increases in MCT PC 20 with inhaled corticosteroid treatment (vs placebo). Our findings additionally suggest that LTRAs can cause false negative MCT results.…”

Section: Discussionmentioning

confidence: 94%

Performance Characteristics of Spirometry With Negative Bronchodilator Response and Methacholine Challenge Testing and Implications for Asthma Diagnosis

Selvanathan¹,

Aaron²,

Sykes³

et al. 2020

Chest

View full text Add to dashboard Cite

BACKGROUND:In patients with a history suggestive of asthma, diagnosis is usually confirmed by spirometry with bronchodilator response (BDR) or confirmatory methacholine challenge testing (MCT). RESEARCH QUESTION: We examined the proportion of participants with negative BDR testing who had a positive MCT (and its predictors) result and characteristics of MCT, including effects of controller medication tapering and temporal variability (and predictors of MCT result change), and concordance between MCT and pulmonologist asthma diagnosis.STUDY DESIGN AND METHODS: Adults with self-reported physician-diagnosed asthma were recruited by random-digit dialing across Canada. Subjects performed spirometry with BDR testing and returned for MCT if testing was nondiagnostic for asthma. Subjects on controllers underwent medication tapering with serial MCTs over 3 to 6 weeks. Subjects with a negative MCT (the provocative concentration of methacholine that results in a 20% drop in FEV 1 [PC 20 ] > 8 mg/mL) off medications were examined by a pulmonologist and had serial MCTs after 6 and 12 months.RESULTS: Of 500 subjects (50.5 AE 16.6 years old, 68.0% female) with a negative BDR test for asthma, 215 (43.0%) had a positive MCT. Subjects with prebronchodilator airflow limitation were more likely to have a positive MCT (OR, 1.90; 95% CI,. MCT converted from negative to positive, with medication tapering in 18 of 94 (19.1%) participants, and spontaneously over time in 25 of 165 (15.2%) participants. Of 231 subjects with negative MCT, 28 (12.1%) subsequently received an asthma diagnosis from a pulmonologist.

show abstract

Section: Discussionmentioning

confidence: 94%

Performance Characteristics of Spirometry With Negative Bronchodilator Response and Methacholine Challenge Testing and Implications for Asthma Diagnosis

Selvanathan¹,

Aaron²,

Sykes³

et al. 2020

Chest

View full text Add to dashboard Cite

show abstract

“…One potential benefit of AIT is that children with asthma who complete AIT can successfully step down to lower steps of treatment regimens, ultimately requiring fewer inhaled medications or lower doses of inhaled medications. 21 , 22 Prospective clinical trials are needed to determine whether children with severe asthma can safely use biological medications to initiate immunotherapy, and subsequently discontinue the biological medications as the disease modifying effects of immunotherapy are seen.…”

Section: To the Editormentioning

confidence: 99%

Allergen immunotherapy in patients with severe asthma: A need for prospective trials

Huntwork,

Carlson

2024

Pediatric Pulmonology

View full text Add to dashboard Cite

A 2-year step-down withdrawal from inhaled corticosteroids in asthmatic children receiving immunotherapy

Abstract: In the present study, we developed a 2-year step-down and withdrawal strategy from ICSs strategy for allergic asthma children receiving SCIT; the strategy was efficacious and safe.

Cited by 2 publications

References 16 publications

Performance Characteristics of Spirometry With Negative Bronchodilator Response and Methacholine Challenge Testing and Implications for Asthma Diagnosis

Performance Characteristics of Spirometry With Negative Bronchodilator Response and Methacholine Challenge Testing and Implications for Asthma Diagnosis

Allergen immunotherapy in patients with severe asthma: A need for prospective trials

Contact Info

Product

Resources

About