A 24-Year-Old Woman With Cough, Arthralgia, and Skin Ulcerations

Leveque, Thibault; Pavlidi, Anastasia; Lacoste-Palasset, Thomas; Cazes, Aurélie; Messika, Jonathan; Montravers, Philippe; Lortat‐Jacob, Brice; Castier, Yves-Hervé; Bunel, Vincent; Borie, R.; Sène, Damien; Allenbach, Yves; Mégarbane, Bruno; Comarmond, Cloé

doi:10.1016/j.chest.2022.12.038

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Connective Tissue Disease1

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2023

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“…Patients with lung disease related to an idiopathic inflammatory myopathy (IIM), particularly those with anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibodies, are at high risk for rapidly progressive ILD and have a particular poor prognosis. Lung transplantation is an option for patients with lung disease related to an IIM [38], and ECMO is being increasingly used as a strategy to bridge these patients to lung transplantation [39,40]. These patients are at high risk for malignancy [41] and should be carefully screened.…”

Section: Connective Tissue Diseasementioning

confidence: 99%

Lung Transplantation: Selection of Candidates

Thomas,

Williams,

Shlobin

2023

OBM Transplant

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Lung transplantation is a last-resort treatment option for patients with end stage lung disease. The procedure is being performed more frequently and scientific advances continue to be made, but the median post-transplant survival is far shorter than other solid organ transplant recipients. Candidate selection is a resource intensive process that attempts to balance risks of the procedure with the benefits of much higher quality of life. Transplant centers must weigh disease specific considerations, medical comorbidities, and psychosocial factors with the likelihood of a successful transplantation. While the candidate selection process is exceptionally challenging, it leads to many patients undergoing successful lung transplantation.

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