A 28-Year-Old Man With Mediastinal Seminoma Treated With BEP

Abstract

Highlight:A 28-year-old male suffered chylothorax and mediastinal seminoma.The patient received bleomycin, etoposide and cisplatin chemotherapy for the management of mediastinal seminomas but he died beforeundergoing 5th cycle chemotherapy. Abstract:Seminoma is a type of germ cell tumor. In this case presentation, a rare primary germ cell tumor was reported in the form of mediastinal seminoma. A 28-year-old man with symptoms of shortness of breath, chest pain, swelling in the right upper extremity, enlarged lymph nodes in the colli region. Thoracic physical examination revealed signs of pleural fluid in the right hemithorax. After obtaining the results of radiological and pathological investigations, a mediastinal mass was obtained, then BEP chemotherapy was given. After 3 cycles of chemotherapy, a partial response was obtained. Patients with mediastinal seminoma treated with BEP base chemotherapy gave a partial response.

A case of primary mediastinal seminoma with superior vena cava syndrome and large intracardiac thrombus

“…Seminomas do not have a characteristic or specific appearance in the radiological aspect [5] . A CT scan usually presents a seminoma as an essentially homogeneous, non-encapsulated, sometimes lobulated mass, which may compress or invade surrounding tissues.…”

“…A CT scan usually presents a seminoma as an essentially homogeneous, non-encapsulated, sometimes lobulated mass, which may compress or invade surrounding tissues. It may accompany a pleural or pericardial effusion [5] , [6] . In mediastinal tumors, serum tumor markers were examined, including AFP, β-HCG, and LDH [7] .…”

“…The placental alkaline phosphatase (PLAP) test is often positive in mediastinal seminomas. CD117 is usually positive for the cell membrane or para nuclear [1] , [5] .…”