A 3,2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo

Abstract

Searching for actinide decorporation agents with advantages of high decorporation efficiency, minimal biological toxicity, and high oral efficiency is crucial for nuclear safety and the sustainable development of nuclear energy. Removing actinides deposited in bones after intake is one of the most significant challenges remaining in this field because of the instantaneous formation of highly stable actinide phosphate complexes upon contact with hydroxyapatite. Here we report a hydroxypyridinone-based ligand (5LIO-1-Cm-3,2-HOPO) exhibiting stronger affinity for U(VI) compared with the reported tetradentate hydroxypyridinone ligands. This is further revealed by the first principles calculation analysis on bonding between the ligand and uranium. Both in vitro uranium removal assay and in vivo decorporation experiments with mice show that 5LIO-1-Cm-3,2-HOPO can remove uranium from kidneys and bones with high efficiencies, while the decorporation efficiency is nearly independent of the treatment time. Moreover, this ligand shows a high oral decorporation efficiency, making it attractive for practical applications.

DNA nano-pocket for ultra-selective uranyl extraction from seawater

“…Some other functional groups are also used for constructing uranium adsorbents, such as the engineered proteins 16 , 17 , bio-inspired nanostructures 18 – 20 , molecularly imprinted polymer 21 , and the network formed by hydroxyl groups 22 , and show enhanced uranium adsorption selectivity compared with the amidoxime group. These results indicate that the application of novel functional group is a promising strategy for developing novel uranium adsorbents 23 – 26 .…”

Flat crown ethers with planar tetracoordinate carbon atoms

“…It is noted here that Si 2 C 3 -16C4 also forms a complex with uranyl ion, [UO 2 -Si 2 C 3 -16C4] 2+ (see Figure 3). The reason we had tried this particular ion is largely due to the fact that enormous amount of effort had already been devoted in making new chelating agents for UO 2+ 2 62, 63 . into uranyl oxides.…”

“…The reason we had tried this particular ion is largely because an enormous amount of effort had already been devoted in making new chelating agents for UO . [ 95,96 ] Here, we are proposing a new chelating agent for UO whose binding energies are in the range of −213.97 to −238.26 kcal mol −1 .…”

“…[ 95,96] Here, we are proposing a new chelating agent for UO As far as optimal geometry parameters are concerned, the ptC C and ptC Si bond lengths show single bond characteristics (see Tables 2, 4, and 6). Furthermore, quite consistently, the Si C bond length exhibits double bond characteristics (1.75 Å) in all cases.…”

Alkynyl-Based sp 2 Carbon-Conjugated Covalent Organic Frameworks with Enhanced Uranium Extraction from Seawater by Photoinduced Multiple Effects

“…6 Owing to economics and versatility, chemical adsorption is considered to be the most promising technology for extracting uranium from seawater. 7,8 Recently, numerous porous materials have been developed for uranium extraction, [9][10][11][12][13] such as porous aromatic frameworks (PAFs), 14,15 metal-organic frameworks (MOFs), 6,16 and porous organic polymers (POPs); 17 all of them exhibit impressive uranium extraction performance. However, most adsorbents have poor stability in complex marine environments, leading to decomposition during long-term immersion in the ocean.…”