A 3-alkylpyridine-bearing alkaloid exhibits potent antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) with no detectable resistance

Phytochemicals Screening and Antibacterial Activity of Teijsmaniadendron Holrungii from West Papua

“…Most of the alkaloids that are antibacterial and antifungal have a quinoline or indole basic framework, with a target mechanism of inhibition of alkaloid compounds through cross-linking with DNA or protein molecules that cause genetic mutations, topoisomerase inhibition, and damage to the cytoplasmic membrane in bacterial and fungal cells (Herrera et al, 2022;Alghazeer et al, 2022;Sulaiman et al, 2022). Flavonoid compounds have been identified as polyphenolic compounds with antibacterial activity through various mechanisms.…”

A Hybrid Antimicrobial Peptide Targeting Staphylococcus aureus with a Dual Function of Inhibiting Quorum Sensing Signaling and an Antibacterial Effect

“…41,42 Therefore, targeted inhibition of the QS system is a typical antivirulence strategy that may be effective against S. aureus pathogens. 43−45 AIP is a signaling molecule in the agr system, 41,46,47 Once AIP reaches the threshold concentration, cognate AIP activates the transmembrane receptor AgrC, resulting in upregulated expression of virulence factors and the promotion of biofilm formation. 16,48,49 A cognate AIP-agrC pair interaction leads to group-specific agr activation, whereas a noncognate AIP-agrC pair interaction inhibits the agr response.…”

“…aureus infections, , and are primarily regulated by the agr system, which controls biofilm formation and secretion of virulence factors. , Therefore, targeted inhibition of the QS system is a typical antivirulence strategy that may be effective against S. aureus pathogens. − AIP is a signaling molecule in the agr system, ,, Once AIP reaches the threshold concentration, cognate AIP activates the transmembrane receptor AgrC, resulting in upregulated expression of virulence factors and the promotion of biofilm formation. ,, A cognate AIP-agrC pair interaction leads to group-specific agr activation, whereas a noncognate AIP-agrC pair interaction inhibits the agr response. , Many studies on blocking QS in S. aureus have focused on AIP ligands. ,, Tal-Gan et al modified the native AIP-III structure by replacing Asp with Ala and constructed a highly potent inhibitor called AIP-III D4A .…”