A 3-month double-blind randomised study comparing an olive oil- with a soyabean oil-based intravenous lipid emulsion in home parenteral nutrition patients

Abstract

Intravenous lipid emulsions (ILE) have demonstrated advantages including prevention of essential fatty acid (EFA) deficiency; however, too much EFA can down regulate fatty acid elongation leading to an imbalance of nutritional compounds in plasma and cell membranes. An olive oil-based ILE containing long-chain triacylglycerols (LCT) with a low content (20 %) of PUFA was administered for home parenteral nutrition (HPN) and compared with a conventional soyabean oil-based ILE (PUFA content, 60 %). Thirteen patients (26-92 years) with stable intestinal failure were randomised after a 1-month run-in period with a medium-chain triacylglycerols-LCT-based ILE, to receive 3 months of HPN with either olive oil-(n 6) or soyabean oil-based (n 7) ILE. The nutritional impact and safety of HPN, oral intakes and absorption rates, phospholipid fatty acids in plasma and lymphocyte cell membrane were assessed. The only clinical event reported was one case of pneumonia (soya group). In both groups, 20 : 3n-9:20 : 4n-6 ratios remained within normal ranges (0·03-0·07). There was a significant increase of g-linolenic acid (g-LA) in plasma and lymphocyte cell membrane (P¼ 0·02) and of oleic acid in plasma (P,0·01) in the olive compared with the soya group. A significant correlation was found between g-LA (day 90 -day 0) in plasma and PUFA parenteral intakes (P¼ 0·02), but neither with fat intakes nor with fat absorption rates. In conclusion, plasma and lymphocyte EFA pattern remained in normal ranges without EFA deficiency with both lipid emulsions, despite a lower content of n-3 and n-6 series with the olive oil-based ILE.

Treatment of Rat Spinal Cord Injury with the Neurotrophic Factor Albumin-Oleic Acid: Translational Application for Paralysis, Spasticity and Pain

“…In addition the measurement of Tibialis Anterior reflex activity using standard spinal and a newly developed translational measure of descending function assures the clinical relevance of the effect of Alb-OA as a novel neurotrophic factor in vivo following central neurotrauma. The potentially safe clinical profile of this complex [50] and to the possibility that specific SCI symptoms of spinal change in nociceptive function and spasticity could be treated with Alb-OA is discussed below.…”

Olive oil in parenteral nutrition

“…In addition, and in contrast what is observed in infants, there is no effect on antioxidant status or on lipid peroxidation. Another recent study by Vahedi et al [52 ] compared ClinOleic and Ivelip in adult patients over 3 months, comparing clinical and metabolic effects. There were no differences in routine blood parameters including liver enzymes between the two groups and no differences in hepatobiliary function.…”

Maximizing efficacy from parenteral nutrition in critical care: Appropriate patient populations, supplemental parenteral nutrition, glucose control, parenteral glutamine, and alternative fat sources

“…As compared with a lipid emulsion rich in PUFA, this formulation has not been demonstrated to depress cell-mediated immunity [67]. The safety and nutritional efficacy of this lipid emulsion has been demonstrated in patients receiving home PN and in preterm infants [68,69]. There are limited data evaluating the benefit of this emulsion in critically ill patients.…”