A 3-month-old baby with H1N1 and Guillain-Barre syndrome

Vasconcelos, Alexandra; Abecasis, Francisco; Monteiro, Rita Lencastre; Camilo, Cristina; Vieira, Marisa; Carvalho, Mamede de; Correia, Manuela

doi:10.1136/bcr.12.2011.5462

Cited by 9 publications

(8 citation statements)

References 23 publications

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“…Moreover, these NCSs revealed demyelinating neuropathy in some patients with GBS-I (5/13, 38%), whereas axonal neuropathy was relatively less common (2/13, 15%). 1,18–23 Those are in accord with the current findings.…”

Section: Discussionsupporting

confidence: 92%

Guillain-Barré syndrome and related diseases after influenza virus infection

Yamana¹,

Kuwahara²,

Fukumoto³

et al. 2019

Neurol Neuroimmunol Neuroinflamm

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ObjectiveWe examined the clinical and serologic features of Guillain-Barré syndrome (GBS)-related diseases (GBSRDs), including GBS, Fisher syndrome (FS), and Bickerstaff brainstem encephalitis (BBE), after influenza virus infection (GBSRD-I) to reveal potential underlying autoimmune mechanisms.MethodsWe retrospectively investigated the presence of antiglycolipid antibodies against 11 glycolipids and the clinical features of 63 patients with GBSRD-I. Autoantibody profiles and clinical features were compared with those of 82 patients with GBSRDs after Campylobacter jejuni infection (GBSRD-C).ResultsThe anti-GQ1b seropositivity rate was significantly higher, whereas the GM1 and GD1a seropositivity rates were significantly lower in GBSRD-I compared with GBSRD-C. Anti-GQ1b and anti-GT1a were the most frequently detected antiglycolipid antibodies in GBSRD-I (both 15/63, 24%). Consequently, FS was more frequent in GBSRD-I than GBSRD-C (22% vs 9%, p < 0.05). In addition, as for GBS, cranial nerve deficits, sensory disturbances, and ataxia were more frequent in the cases after influenza infection (GBS-I) than in those after C. jejuni infection (GBS-C) (46% vs 15%, 75% vs 46%, and 29% vs 4%, respectively; all p < 0.01). Nerve conduction studies revealed acute inflammatory demyelinating polyneuropathy (AIDP) in 60% of patients with GBS-I but only 25% of patients with GBS-C (p < 0.01).ConclusionsAnti-GQ1b antibodies are the most frequently detected antibodies in GBSRD-I. Compared with GBS-C, GBS-I is characterized by AIDP predominance and frequent presence of cranial nerve involvement and ataxia.

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Section: Discussionsupporting

confidence: 92%

Guillain-Barré syndrome and related diseases after influenza virus infection

Yamana¹,

Kuwahara²,

Fukumoto³

et al. 2019

Neurol Neuroimmunol Neuroinflamm

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“…A total of 115 articles were initially retrieved, but eleven of them were eliminated according to our exclusion criteria. Finally, considering our inclusion criteria, only 104 articles (1636 patients) were included and divided into two groups, according to the origin of neurological complications: influenza vaccine‐related (287 patients) or viral infection‐related (1349 patients) (Tables S1 and S2) . The main characteristics of patients are summarized in Table .…”

Section: Resultsmentioning

confidence: 99%

Neurological events related to influenza A (H1N1) pdm09

Cárdenas

Soto-Hernández

Díaz-Alba

et al. 2014

Influenza Resp Viruses

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ObjectivesTo review neurological complications after the influenza A (H1N1) pdm09, highlighting the clinical differences between patients with post-vaccine or viral infection.DesignA search on Medline, Ovid, EMBASE, and PubMed databases using the keywords “neurological complications of Influenza AH1N1” or “post-vaccine Influenza AH1N1.”SettingOnly papers written in English, Spanish, German, French, Portuguese, and Italian published from March 2009 to December 2012 were included.SampleWe included 104 articles presenting a total of 1636 patient cases. In addition, two cases of influenza vaccine-related neurological events from our neurological care center, arising during the period of study, were also included.Main outcome measuresDemographic data and clinical diagnosis of neurological complications and outcomes: death, neurological sequelae or recovery after influenza A (H1N1) pdm09 vaccine or infection.ResultsThe retrieved cases were divided into two groups: the post-vaccination group, with 287 patients, and the viral infection group, with 1349 patients. Most patients in the first group were adults. The main neurological complications were Guillain-Barre syndrome (GBS) or polyneuropathy (125), and seizures (23). All patients survived. Pediatric patients were predominant in the viral infection group. In this group, 60 patients (4.7%) died and 52 (30.1%) developed permanent sequelae. A wide spectrum of neurological complications was observed.ConclusionsFatal cases and severe, permanent, neurological sequelae were observed in the infection group only. Clinical outcome was more favorable in the post-vaccination group. In this context, the relevance of an accurate neurological evaluation is demonstrated for all suspicious cases, as well as the need of an appropriate long-term clinical and imaging follow-up of infection and post-vaccination events related to influenza A (H1N1) pdm09, to clearly estimate the magnitude of neurological complications leading to permanent disability.

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“…Guillain-Barré syndrome is a peripheral polyneuroradiculopathy with acute onset. 9,10 The clinical presentation typically consists of a rapidly progressive and symmetric flaccid tetraparesis, more severe distally, associated with absent deep tendon reflexes. It is also known as Landry's paralysis and frequently preceded by an unspecified infection.…”

Section: Discussionmentioning

confidence: 99%

Acute Motor Axonal Neuropathy in a 5-Month-Old Child

Sullo

Motta

Smilari

et al. 2019

Journal of Pediatric Neurology

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Guillain–Barré syndrome (GBS) is an acute inflammatory polyneuropathy characterized by rapidly progressive, essentially symmetric weakness and areflexia in a previously otherwise healthy child. It is the most common cause of acute flaccid paralysis in children, and its reported incidence is 1 to 2/100,000 population. Prior infection is a well-established predating event in GBS. The commonly recognized variants of GBS are acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN), acute motor sensory axonal neuropathy, and Miller–Fisher syndrome. AIDP is the most prevalent form. As Guillain–Barrè syndrome represents an important differential diagnosis in infancy with pronounced and progressive hypotonia, we herein report a case of AMAN in a 5-month-old male infant without known exposure to immunomodulating factors or infections.

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A 3-month-old baby with H1N1 and Guillain-Barre syndrome

Cited by 9 publications

References 23 publications

Guillain-Barré syndrome and related diseases after influenza virus infection

Guillain-Barré syndrome and related diseases after influenza virus infection

Neurological events related to influenza A (H1N1) pdm09

Acute Motor Axonal Neuropathy in a 5-Month-Old Child

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