A 3’UTR Polymorphism of IL-6R Is Associated with Chinese Pediatric Tuberculosis

Abstract

Background. IL-6 is a proinflammatory cytokine that plays a critical role in host defense against tuberculosis (TB). Genetic polymorphisms of IL-6 and its receptor IL-6R had been discussed in adult TB recently. However, their role in pediatric TB is still unclear. Due to the obvious differences in TB pathophysiology in children, which may also reflect differences in genetic background, further association studies in pediatric populations are needed. Methods. A case-control study was carried out in a Chinese pediatric population including 353 TB patients and 400 healthy controls. Tag-SNPs of IL-6 and IL-6R genes were selected by Haploview software, genotyped using MassArray, and analyzed statistically. Results. One polymorphism, rs2229238, in the 3'UTR region of IL-6R was observed to be associated with increased resistance to TB (adjusted P = 0.03). The rs2229238 T allele contributed to a reduced risk to TB in recessive heritable model (OR, 0.53; 95% CI, 0.35–0.78). Conclusions. By tag-SNP genotyping based case-control study, we identified a genetic polymorphism in the IL-6R 3'UTR that regulates host resistance to pediatric TB in a Chinese population.

Association between the <em>IL-6</em> gene polymorphism and tuberculosis risk: a meta-analysis

“…A total of 12 publications with 2635 cases and 3049 controls were justified eligible according to inclusion criteria. 7 , 17 , 18 , 25 – 33 Figure 1 outlines the selection and inclusion process of publications.…”

“…Among the included publications, eight evaluated the association between the IL-6 (−174G/C) polymorphism and tuberculosis risk, with 959 cases and 1608 controls; 7 , 18 , 25 – 30 three focused on IL-6 (−572C/G) polymorphism, including 686 cases and 725 controls. 17 , 32 , 33 One article assessed both IL-6 (−174G/C) and (−572C/G) with 495 cases and 358 cases, 18 and it was treated as two independent studies in the present meta-analysis. Consequently, 13 studies were available for analyzing the association between IL-6 gene polymorphism and tuberculosis risk, nine (8 publications) of them were conducted in Asians, 17 , 18 , 25 , 27 , 29 , 30 , 32 , 33 while two were in Caucasians, 26 , 28 and two were in Latinos.…”

Characterization of plasma proteins in children of different Mycobacterium tuberculosis infection status using label-free quantitative proteomics

“…A total of 72 children (19 ATB, 16 LTBI, 17 IDC and 20 HC) were enrolled at Beijing Children's Hospital between July 2010 to May 2013. The diagnosis of pediatric ATB was according to the guidelines of the Chinese Medical Association: (1) MTB culture result was positive, or (2) at least one symptom, sign, or radiographic evidence was consistent with ATB, or (3) clinical and radiological improvement was seen following anti-TB chemotherapy [2]. To accurately reflect the MTB infection status, all the ATB sera were collected before anti-TB chemotherapy.…”

“…Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), continues to be a serious infectious disease worldwide [1,2]. It is estimated that most active TB (ATB) cases originate from an initial latent TB infection (LTBI), a state without any clinical symptoms, radiological abnormality, and microbiological evidence.…”

Association of interleukin-6 gene polymorphism (rs1800796) with severity and functional status of osteoarthritis in elderly individuals

“…Despite there are several SNP of the IL6 gene, the most studied ones related to promoter positions (À597, À572 and À174) correspond to SNP reference numbers of rs1800797, rs1800796 and rs180095, respectively [24].…”