A 3 year audit of adult epilepsy care in a Nigerian tertiary hospital (2011-2013)

Sanya, Emmanuel; Wahab, Kolawole; Desalu, Olufemi Olumuyiwa; Bello, Hamsat Abiodun; Ademiluyi, Babatunde; Alaofin, Wemimo; Busari, K.

doi:10.4103/1596-3519.149878

Cited by 5 publications

(2 citation statements)

References 22 publications

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“…[3235] In Nigeria, the prevalence of nonadherence was found to be 21% and in Uganda it was 46%. [3440] The percentage was higher in a study which looked into the mortality of epilepsy among patients in an endemic area with onchocerciasis in Uganda (64%). [41] These differences in the level of adherence might be attributed to social, environmental, and racial differences.…”

Section: Discussionmentioning

confidence: 99%

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Factors affecting adherence to antiepileptic medications among Sudanese individuals with epilepsy: A cross-sectional survey

Elsayed

Badi

et al. 2019

J Family Med Prim Care

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Background: Nonadherence to medication is widespread in epilepsy and other chronic diseases. Studies reporting adherence to antiepileptic medications are very limited in African countries. Adherence reports from low income African countries are few in contrast to multiple studies from high-income countries. Therefore, the aim of this study is to measure the level of adherence to antiepileptic medication in Sudanese population. Methods: A descriptive cross-sectional study of 96 individuals with epilepsy recruited from neurology outpatient clinics in three tertiary centers in Sudan. Data were collected by using a structured questionnaire containing Morisky Medication Adherence Scale-4 (MMAS-4) and Belief about Medication Questionnaire and analyzed by statistical package of social sciences. Results: About 35% of patients were estimated to be nonadherent. Most of the patients (93%) acknowledged their need for antiepileptic drugs. However, 35% had high concern score. Adherence is affected by attitude toward antiepileptic drugs (AEDs) and presence of side effects to AEDs. The relation between side effects and adherence was significant ( P value 0.000). Furthermore, there was a statistically insignificant relation between the number of drugs used and adherence ( P value 0.002). There was a significant relation between adherence, necessity mean score, concern mean score, and necessity concern differential P value 0.000 for all. Conclusion: Nonadherence to antiepileptic medication was reported in almost in one third of individuals in this cohort. There were statistically significant associations between nonadherence and both side effects and number of medications used in the treatment of epilepsy. Therefore, family physician should always check compliance with antiepileptic medication. Patient's education about adherence to medication through family physician may in part decrease the recurrence of epileptic seizures. Further research is needed to explore ways to increase adherence with AEDs in a low resource country like Sudan.

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Section: Discussionmentioning

confidence: 99%

“…[29] In Nigeria, Sanya et al showed that 21 (21%) did not comply with the use of given AED. [34] While in a primary care study in the UK showed that 36% of the patients were nonadherent. A total of 15% had low necessity scores, while 36% had strong concerns about AEDs, i.e.…”

Section: Introductionmentioning

confidence: 99%

Factors affecting adherence to antiepileptic medications among Sudanese individuals with epilepsy: A cross-sectional survey

Elsayed

Badi

et al. 2019

J Family Med Prim Care

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Evaluating the impact of pharmaceutical care services on the clinical outcomes of epilepsy: a randomised controlled trial

2021

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Clinical characteristics of children with epilepsy managed at an urban hospital in Africa: a retrospective study

Samia¹,

Barr

Levi

et al. 2019

JICNA

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Background Most children with epilepsy reside in resource-limited regions such as sub-Saharan Africa, where the majority of studies have been conducted in rural areas with limited investigations. Medical records from children with epilepsy seen at an urban hospital in Kenya were examined to provide a comprehensive description of epilepsy in children from this hospital. Methods A retrospective observational study was conducted which involved reviewing medical records of 426 epilepsy patients (260 males and 166 females) aged 0 - 18 years, seen at Aga Khan University Hospital, Nairobi, Kenya between February 2011 and December 2014. Results The most frequent age at presentation; documented in 29% was in infancy. Generalized seizures due to structural brain abnormalities were the most common form of epilepsy (28%). Lennox-Gastaut Syndrome was the most common electroclinical syndrome (7%). Focal seizures and focal seizures with loss of awareness were identified in 12% of the population. There were no cases of childhood absence epilepsy in this group. Brain atrophy was the most common MRI finding, occurring in a fifth of the population (20%), while cystic encephalomalacia occurred in 13%. Half (50%) of all EEG recordings performed for this cohort were abnormal. Generalized seizures due to structural brain abnormalities and Lennox-Gastaut Syndrome (LGS) were significant predictors of a treatment history of three or more AEDs. At the conclusion of the review period, 16% of the patients had not visited the clinic for more than 12 months and were considered to be lost to follow-up. Conclusion The highest frequency of epilepsy cases was documented in children less than one year of age. Generalized seizures due to structural abnormalities and Lennox-Gastaut syndrome were the most common seizure type and syndrome. Improvement of public awareness of different types of seizures in children may increase identification of children with childhood absence epilepsy.

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A 3 year audit of adult epilepsy care in a Nigerian tertiary hospital (2011-2013)

Abstract: Less than half of our patients had good epilepsy control. To improve on drug compliance attending physicians need to prescribe more of the relatively cheaper AED like the phenobarbitone and to optimize drug dosage before switching to another.

Cited by 5 publications

References 22 publications

Factors affecting adherence to antiepileptic medications among Sudanese individuals with epilepsy: A cross-sectional survey

Factors affecting adherence to antiepileptic medications among Sudanese individuals with epilepsy: A cross-sectional survey

Evaluating the impact of pharmaceutical care services on the clinical outcomes of epilepsy: a randomised controlled trial

Clinical characteristics of children with epilepsy managed at an urban hospital in Africa: a retrospective study

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