A 3-year prospective study of neurological soft signs in first-episode schizophrenia

Chen, Eric; Hui, Christy Lai Ming; Chan, Raymond C. K.; Dunn, Eva Lai-Wah; Miao, May Yin-King; Yeung, Wai-Song; Wong, C.K.; Chan, Wah-Fat; Tang, Wai-Nang

doi:10.1016/j.schres.2004.09.002

Cited by 79 publications

(67 citation statements)

References 46 publications

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“…The present finding is consistent with the conclusion that schizophrenia patients have a motion perception deficit attributable to dysfunction in extrastriate cortex area MT (see, e.g., Chen et al, 2005;Lencer et al, 2005). These data also are consistent with the theory of specific magnocellular pathway dysfunction in schizophrenia (Kim et al, 2006), since this pathway provides majority input to motion area MT (Maunsell et al, 1990).…”

Section: Discussionsupporting

confidence: 92%

“…It seems unlikely that elevated motion perception in schizophrenia can be accounted for by these factors. First, in other studies of motion detection and analysis, schizophrenia patients have had normal abilities to detect either the presence/absence or direction of motion using grating stimuli (e.g., Chen et al, 2003;Chen et al, 2005). Second, in smooth pursuit studies, schizophrenia patients have normal pursuit maintenance if prediction is not required even though pursuit onset is abnormal (Clementz & McDowell, 1994).…”

Section: Discussionmentioning

confidence: 99%

“…When presented with dynamic random dot patterns, schizophrenia patients require an unusually high proportion of coherently moving dots to discern the pattern's global direction (Stuve et al, 1997;Chen et al, 2003;Chen et al, 2005;Kim et al, 2006;O'Donnell et al, 2006). Schizophrenia patients also are worse at discerning speed differences between two paired moving gratings (Chen et al, 2004;O'Donnell et al, 2006;Slaghuis et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Compromised speed discrimination among schizophrenia patients when viewing smooth pursuit targets

Clementz

McDowell

Dobkins

2007

Schizophrenia Research

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Schizophrenia subjects' smooth pursuit abnormalities may reflect a problem with perception of motion, although evidence comes primarily from reports using stimuli that differ from standard smooth pursuit stimuli (i.e moving gratings or coherent dots). This study presented schizophrenia and healthy subjects with a forced choice speed discrimination paradigm using smooth pursuit-like stimuli. The schizophrenia subject's motion processing was impaired, as evidenced by their significantly higher speed discrimination thresholds (a difference that was 1.7 larger for the patient group). Abnormalities of motion perception in schizophrenia, even for simple stimuli, suggest a problem with motion processing in area MT.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Compromised speed discrimination among schizophrenia patients when viewing smooth pursuit targets

Clementz

McDowell

Dobkins

2007

Schizophrenia Research

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“…A total of 402 papers were identified by the search strategy, from which we identified 28 non-overlapping first episode studies that met inclusion criteria (see Appendix 1) (Montague et al, 1989;Barnes et al, 2000;Craig et al, 2000;de Haan et al, 2000;Drake et al, 2000;Ho et al, 2000;Larsen et al, 2000;Black et al, 2001;Verdoux et al, 2001;Cullberg et al, 2002;Malla et al, 2003;Addington et al, 2004;Sim et al, 2004;Chen et al, 2005;Harris et al, 2005;Manchanda et al, 2005;Melle et al, 2005;Oosthuizen et al, 2005;Petersen et al, 2005;Wade et al, 2005;Clarke et al, 2006;Ucok et al, 2006;Wunderink et al, 2006;Crespo-Facorro et al, 2007;Malla et al, 2007;Vyas et al, 2007;Gorna et al, 2008;Yamazawa et al, 2008). The selected studies included a total of 3998 participants.…”

Section: Studies and Patientsmentioning

confidence: 99%

Duration of untreated psychosis and negative symptoms — A systematic review and meta-analysis of individual patient data

Boonstra

Klaassen

Sytema

et al. 2012

Schizophrenia Research

211

134

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Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Background: Longer duration of untreated psychosis (DUP) is associated with poorer outcome in terms of positive symptoms, relapse rate, and time to remission. In contrast, the association with negative symptoms is less consistent. Aims: The study had three aims. First, to arrive at a more precise estimate of the correlation between DUP and negative symptoms than previous reviews, by substantially increasing the amount of available data. Second, to see whether the strength of this correlation attenuated over longer follow-up intervals. Third, to determine whether there is a relationship between DUP and changes in negative symptoms. Method: Relevant databases were searched for studies published between December 1992 and March 2009 that reported data on DUP and negative symptoms. We obtained individual patient data where possible and calculated summary correlations between DUP and negative symptoms for each study at baseline, short and long-term follow-up. We used multilevel regression analysis to examine whether the effect of DUP on negative symptoms was the greatest in the early stages of illness. Results: We included 28 non-overlapping studies from the 402 papers detected by the search strategy. After contacting the authors we obtained individual patient data from 16 of these studies involving 3339 participants. The mean DUP was 61.4 weeks (SD = 132.7, median DUP = 12.0). Shorter DUP was significantly associated with less severe negative symptoms at baseline and also at short (1-2 years) and longer term follow-up (5-8 years) (r = 0.117, 0.180 and 0.202 respectively, p b 0.001). The relationship between improvement in negative symptoms and DUP was found to be non-linear: people with a DUP shorter than 9 months showed substantially greater negative symptom reduction than those with a DUP of greater than 9 months. Conclusions: Shorter DUP is associated with less severe negative symptoms at short and long-term follow up, especially when the DUP is less than 9 months. Since there is no effective treatment for negative symptoms, reducing DUP to less than 9 months may be the best way to ameliorate them.

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“…Evidence that these deficits have some heritability [38], show familial association [39] and may be state independent [40] suggests that future studies of neurological and neurocognitive tests involving motor skills could establish whether these deficits meet all the requirements needed by a good endophenotype. If this is the case, a short targeted assessment of these specific domains would be easier to implement in the research and clinical setting than a full neurological and neurocognitive evaluation.…”

Section: A Possible Interpretationmentioning

confidence: 99%

Which neurological abnormalities and neuropsychological impairments share the same substrate in psychosis?

Dazzan

Chan

2011

Chin. Sci. Bull.

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A 3-year prospective study of neurological soft signs in first-episode schizophrenia

Cited by 79 publications

References 46 publications

Compromised speed discrimination among schizophrenia patients when viewing smooth pursuit targets

Compromised speed discrimination among schizophrenia patients when viewing smooth pursuit targets

Duration of untreated psychosis and negative symptoms — A systematic review and meta-analysis of individual patient data

Which neurological abnormalities and neuropsychological impairments share the same substrate in psychosis?

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