In this paper, a steady-state matrix analysis method is introduced to analyze the output characteristics of the class-E power amplifier used in a wireless power transfer (WPT) system, which takes the inductance resistance, on-resistance and leakage current of metal-oxide-semiconductor field effect transistor (MOSFET) into account so that the results can be closer to the actual value. On this basis, the parameters of the class-E power amplifier are optimized, and the output power is improved under the premise of keeping the efficiency unchanged. Finally, the output characteristics of the amplifier before and after optimization are compared by an experiment, while the B-field strength around the WPT system is studied through simulation. The experimental results verify the correctness and feasibility of the optimization method based on steady-state matrix analysis.