A 3D nanostructured calcium-aluminum-silicate scaffold with hierarchical meso-macroporosity for bone tissue regeneration: Fabrication, sintering behavior, surface modification and in vitro studies

Bigham, Ashkan; Aghajanian, Amir Hamed; Movahedi, Mehdi; Sattary, Mansoureh; Rafienia, Mohammad; Tayebi, Lobat

doi:10.1016/j.jeurceramsoc.2020.07.073

Cited by 32 publications

(15 citation statements)

References 86 publications

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“…The porosities of various SiCa and composite scaffolds have been measured using the aforementioned methods: liquid displacement (distilled water), [ 33,49,50,59,67,68,70,71,74,88–120 ] liquid displacement (ethanol), [ 121–125 ] liquid displacement (hexane), [ 126–129 ] liquid displacement (kerosene), [ 130 ] mercury intrusion, [ 131–135 ] gravimetry [ 45,65,110,136–138 ] , μ‐CT, [ 114,116,139–145 ] 1, and SEM [ 75,84,85,143,146–150 ] according to the literature.…”

Section: Methods To Measure the Porosity Of Porous Scaffoldsmentioning

confidence: 99%

“…Such polymeric coatings were found to decrease the pore size and increase the compressive strength. [84,94,117,118,120,121,141] For instance, the PCL coating enhanced the compressive strength of a baghdadite scaffold. This is because of the chemical reaction between the silanol group Si─O─H and the hydroxyl group in PCL on the surface of the scaffold, forming a strong bond between the ceramic matrix and the polymer coating.…”

Section: Effect Of Coatingmentioning

confidence: 99%

“…Applying a polymer coating on the ceramic scaffold can improve the compressive strength of the scaffold. [196] Hitherto, various polymers such as polycaprolactone fumarate (PCLF), [94,118] polycaprolactone (PCL), [84,118,120,121,141] poly(lactic-co-glycolic acid) (PLGA) [96,98,101] and silk [59,128,150] have been used as coating on SiCa scaffolds. Such polymeric coatings were found to decrease the pore size and increase the compressive strength.…”

Section: Effect Of Coatingmentioning

confidence: 99%

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How Does Scaffold Porosity Conduct Bone Tissue Regeneration?

et al. 2021

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Despite progresses in tissue healing, repairing large bone defects remains an unmet challenge. Tissue engineering (TE) using porous scaffolds offers great promise in providing solutions by which bone healing can be increased, and the need for further surgical intervention can be reduced. Nonetheless, the successful performance of a porous scaffold depends on key structural factors including porosity, pore size, geometry, and interconnectivity. Herein, recent advancements on this topic are reviewed and the effects of fabrication methods on making potential scaffolds for advanced bone regeneration are discussed.The upward trend of population aging, increased numbers of accidents, sport injuries, trauma, and bone tumor resection are increasing the demand for substitutes to regenerate and/or repair damaged skeletal and dental bones. [1] Bone tissue poses a simple yet highly organized ultracomposition in which each portion plays a pivotal role in moderating the elasticity and strength of the bone. [2] The intrinsically dynamic bone tissue structure allows the restoration of damaged parts via the self-healing process. [3] This remodeling process is dependent on the dynamic equilibrium between the bone-forming (osteoblast) and bone-resorbing cells (osteoclast) during mechanical stimulation. [4] Nevertheless, this healing process is not sufficient for repairing massive and critical bone defects; thus, there is a need for drastic healing accelerators and substitutive or supportive therapeutics. [5] Specially, the regenerating of large bone defects is a serious and challenging clinical issue. To address the issue, different types of bone graft substitutes such as autografts, allografts, and xenografts are used. [6] These grafts, however, come with certain drawbacks, including donor site morbidity and limited supply. Moreover, aged persons cannot provide rich bone tissue for their own tissue replacement due to osteoporosis. [7] To address the limitations associated with natural bone-derived substitutes, biomaterials have been developed during recent decades. [8] Engineering biomaterials made it possible to simulate the bone microenvironment and construct programmable scaffolds for purposeful therapeutic procedures. Bioactive ceramic materials are favorable for bone tissue engineering (BTE) due to their resemblance to the mineral phase of bone, and direct bonding with host bone tissue without the formation of fibrous tissue. In addition, the variety in the chemical composition of bioceramics, particularly silicate-based ceramics (SiCa), can contribute to adjustments in mechanical properties, bioactivity, and biodegradability.A fundamental constituent of engineering tissue is the scaffold, which acts as the structural template providing a suitable substrate for cell proliferation, differentiation, and attachment resulting in new tissue formation. In tissue engineering (TE), the scaffold serves as the structural guide and the substrate for cell anchorage. The scaffold also contributes to the remodeling of the extracellular mat...

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Section: Methods To Measure the Porosity Of Porous Scaffoldsmentioning

confidence: 99%

Section: Effect Of Coatingmentioning

confidence: 99%

Section: Effect Of Coatingmentioning

confidence: 99%

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How Does Scaffold Porosity Conduct Bone Tissue Regeneration?

et al. 2021

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“…Besides calcium phosphate‐based materials, a study took advantage of a calcium zirconium silicate mineral called baghdadite to be concocted with nylon 6 for bone tissue regeneration 89 . It was reported that the incorporation of different ions into the crystal structure of silicate‐based materials would significantly improve their mechanical properties and these materials were proven to outperform the calcium phosphate and bioactive glass ceramics in physicochemical properties 90,91 . The baghdadite/nylon 6 nanocomposite was turned out to be much more desirable for bone tissue regeneration in cell compatibility, bioactivity, biodegradation, and mechanical properties than pure nylon 6 89 …”

Section: Regenerative Medicinementioning

confidence: 99%

Nylon—A material introduction and overview for biomedical applications

Shakiba

Ghomi

Khosravi

et al. 2021

Polymers for Advanced Techs

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138

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Nylon is a human‐made material and has been applied in many industrial fields. This literature review explores the use of nylon in biomedical applications and discusses the properties and three‐dimensional (3D) printability of this material. Nylon is studied due to its versatility as an engineering plastic that can be easily transformed into fibers, films, and molded parts. Due to nylon's biocompatible nature, it has desirable chemical stability and tunable mechanical properties making this material and its derivatives widely used as sutures, catheters, dentures, and so on. However, the interactions between nylon and human body tissues have yet to be fully understood. Nevertheless, nylon is hybridized with different materials and used as skin dressings. In recent years, nylon composites have been actively researched in tissue engineering as an alternative to metallic implants with an appropriate bioactivity potential for bone growth. As nylon is supposed to be in contact with the tissue for a long time, hence researchers are developing antimicrobial strategies for the nylon materials to even promote their potential a step further. The 3D printing of nylon is currently confined to specific applications due to the printing technology's current limitations.

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“…Gehlenite (GLN, Ca 2 Al 2 SiO 7 ) belongs to CSBs family in which Al 3+ ions are inserted into the structure of calcium silicate. Previous studies reported that GLN's mechanical properties including flexural strength, Young's modulus, and fracture toughness are 142 ± 12.1 MPa, 108 ± 6.8 GPa, and 2.32 ± 0.12 MPa m 1/2 , respectively; the mentioned values are significantly higher than HA, bioglass, and calcium silicate proving the GLN high potential in bone tissue regeneration 26‐28 . In 2016, Roohani‐Esfahani et al 29 for the first time assessed the degradation and cell compatibility of GLN and the results showed that the GLN supports human osteoblast cells attachment and proliferation and also its degradation can be manipulated by changing the sintering temperature.…”

Section: Introductionmentioning

confidence: 98%

A ternary nanocomposite fibrous scaffold composed of poly(ε‐caprolactone)/Gelatin/Gehlenite (Ca₂Al₂SiO₇): Physical, chemical, and biological properties in vitro

Baghbadorani

Bigham

Rafienia

et al. 2020

Polymers for Advanced Techs

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Scaffolds are regarded as 3D substrates providing an appropriate environment through which the cells attachment, proliferation, and differentiation rate can be accelerated; based on their application, these scaffolds must have certain characteristics like suitable mechanical properties and porosity, desired degradation rate, and cell compatibility. In the present study, a novel nanocomposite fibrous scaffold composed of poly(ε‐caprolactone) (PCL)/Gelatin (GT)/Gehlenite (GLN) nanoparticles was fabricated through electrospinning method. Different weight ratios of GLN nanoparticles in the fibrous scaffolds were added and optimized and a series of samples including PCL, PCL/GT, and PCL/GT/GLN scaffolds were constructed in order to reach a better comparison between the scaffolds. It turned out that 7% was the optimized GLN weight ratio to be included into the scaffolds without destroying the fibers structure. Different characterization techniques were applied to assess the physical and chemical properties of scaffolds. Moreover, the scaffolds' degradation rate, bioactivity potential, cell viability, attachment, DAPI and Alizarin staining, and ALP activity were assessed in vitro as well. The overall results indicate that the ternary scaffold (PCL/GT/GLN7%) has a promising potential for bone tissue regeneration.

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A 3D nanostructured calcium-aluminum-silicate scaffold with hierarchical meso-macroporosity for bone tissue regeneration: Fabrication, sintering behavior, surface modification and in vitro studies

Cited by 32 publications

References 86 publications

How Does Scaffold Porosity Conduct Bone Tissue Regeneration?

How Does Scaffold Porosity Conduct Bone Tissue Regeneration?

Nylon—A material introduction and overview for biomedical applications

A ternary nanocomposite fibrous scaffold composed of poly(ε‐caprolactone)/Gelatin/Gehlenite (Ca₂Al₂SiO₇): Physical, chemical, and biological properties in vitro

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A 3D nanostructured calcium-aluminum-silicate scaffold with hierarchical meso-macroporosity for bone tissue regeneration: Fabrication, sintering behavior, surface modification and in vitro studies

Cited by 32 publications

References 86 publications

How Does Scaffold Porosity Conduct Bone Tissue Regeneration?

How Does Scaffold Porosity Conduct Bone Tissue Regeneration?

Nylon—A material introduction and overview for biomedical applications

A ternary nanocomposite fibrous scaffold composed of poly(ε‐caprolactone)/Gelatin/Gehlenite (Ca2Al2SiO7): Physical, chemical, and biological properties in vitro

Contact Info

Product

Resources

About

A ternary nanocomposite fibrous scaffold composed of poly(ε‐caprolactone)/Gelatin/Gehlenite (Ca₂Al₂SiO₇): Physical, chemical, and biological properties in vitro