2014
DOI: 10.4172/2155-983x.1000128
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A 3D Polymer Model for Future Nutrition Design Novel Nutrition Approach for Cystic Fibrosis, Ulcerative Colitis and Crohn`s Disease

Abstract: Introduction Cystic Fibrosis (CF), Ulcerative Colitis (UC), and Crohn’s Disease (CD) manifest as various, multiple symptoms from malfunctioning and/or damaged gastrointestinal tract, which plague the patients. These symptoms result from the dysfunctional expression products of the specific mutations of the genes, which either manifest upon birth (CF) or later in life in immuno-genetically susceptible individuals as inflammatory bowel diseases (IBD). They all may potentially lead to malnutrition of the patients… Show more

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“…This validation of the explant assay is partly done to provide alternatives to drug development in cell-based assays and animal testing. Cell assays are preferred if the study concentrates on an effect in a specific cell type, but generally, a cell layer or even a well-constructed 3D in vitro model for studying IBD lack the complexity of a full and natural microenvironment present in the explant and will not reveal all intercellular pathways, especially without a valid inflammation state[ 17 , 18 , 20 , 21 , 36 , 37 ]. Compared to biopsies, however, cell-based models are readily available and can deliver high-throughput screenings and specific mode-of-action studies.…”
Section: Discussionmentioning
confidence: 99%
“…This validation of the explant assay is partly done to provide alternatives to drug development in cell-based assays and animal testing. Cell assays are preferred if the study concentrates on an effect in a specific cell type, but generally, a cell layer or even a well-constructed 3D in vitro model for studying IBD lack the complexity of a full and natural microenvironment present in the explant and will not reveal all intercellular pathways, especially without a valid inflammation state[ 17 , 18 , 20 , 21 , 36 , 37 ]. Compared to biopsies, however, cell-based models are readily available and can deliver high-throughput screenings and specific mode-of-action studies.…”
Section: Discussionmentioning
confidence: 99%