A 3D-printed bioactive glass scaffold coated with sustained-release PLGA/simvastatin stimulates calvarial bone repair

Chiu, Kuan-Yu; Huang, Jian-Yuan; Su, Ying-Hui; Ou, Shih-Fu; Chen, Ker-Kong; Wang, Yan-Hsiung

doi:10.1016/j.matdes.2024.112898

Cited by 1 publication

(2 citation statements)

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“…The perspective needed here is to provide a structure that both serves as a temporary extracellular matrix until tissue regeneration/formation is achieved and allows the transport and release of active ingredients that will accelerate tissue regeneration. However, the use of small spheres/fibers and lipids may cause sudden release of drugs due to their high surface/volume ratio, or they may be inadequate for tissue growth because they do not have the three-dimensional (3D) compact structure necessary for cellular growth [24]. On the other hand, since ceramic-based scaffoldsneed sintering, the effectiveness of added active ingredients such as drugs and growth factors may disappear at these high temperatures [24].…”

Section: Introductionmentioning

confidence: 99%

“…However, the use of small spheres/fibers and lipids may cause sudden release of drugs due to their high surface/volume ratio, or they may be inadequate for tissue growth because they do not have the three-dimensional (3D) compact structure necessary for cellular growth [24]. On the other hand, since ceramic-based scaffoldsneed sintering, the effectiveness of added active ingredients such as drugs and growth factors may disappear at these high temperatures [24]. Cryogels, a kind of gel system, are one of the most suitable structures that can provide both a temporary extracellular matrix during bone tissue regeneration with its 3D structure and controlled drug release with its interconnected high porosity.…”

Section: Introductionmentioning

confidence: 99%

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Design of gelatin cryogel scaffolds with the ability to release simvastatin for potential bone tissue engineering applications

Yaman,

Demir,

Bölgen

2024

Biomed. Mater.

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Tissue engineering aims to improve or restore damaged tissues by using scaffolds, cells and bioactive agents. In tissue engineering, one of the most important concepts is the scaffold because it has a key role in keeping up and promoting the growth of the cells. It is also desirable to be able to load these scaffolds with drugs that induce tissue regeneration/formation. Based on this, in our study, gelatin cryogel scaffolds were developed for potential bone tissue engineering applications and simvastatin loading and release studies were performed. Simvastatin is lipoliphic in nature and this form is called inactive simvastatin (SV). It is modified to be in hydrophilic form and converted to the active form (SVA). For our study's drug loading and release process, simvastatin was used in both inactive and active forms. The blank cryogels and drug-loaded cryogels were prepared at different glutaraldehyde concentrations (1, 2, and 3%). The effect of the crosslinking agent and the amount of drug loaded were discussed with morphological and physicochemical analysis. As the glutaraldehyde concentration increased gradually, the pores size of the cryogels decreased and the swelling ratio decreased. For the release profile of simvastatin in both forms, we can say that it depended on the form (lipophilic and hydrophilic) of the loaded simvastatin.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%