A 3D-printed bioactive polycaprolactone scaffold assembled with core/shell microspheres as a sustained BMP2-releasing system for bone repair

Zhuang, Weida; Ye, Genlan; Wu, Jiachang; Wang, Leyu; Fang, Guofan; Ye, Zhuofeng; Lai, Guohua; Qiu, Xiaozhong; Sang, Hongxun

doi:10.1016/j.msec.2021.112619

Cited by 16 publications

(9 citation statements)

References 38 publications

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“…1C), resulting in a rougher surface. It is similar to the findings obtained by Zhuang et al 44 and Xu et al , 45 in which a PDA layer coating on the surface of the scaffold indicated starting self-oxidative spontaneous polymerization of Dopa-HCl. As shown by Han et al , 46 successful PDA deposition on the scaffold can be determined by the change in color from light blue to dark brown.…”

Section: Resultssupporting

confidence: 91%

Mussel-inspired polydopamine decorated silane modified-electroconductive gelatin-PEDOT:PSS scaffolds for bone regeneration

Adler,

Monavari,

Abraham

et al. 2023

RSC Adv.

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Section: Resultssupporting

confidence: 91%

Mussel-inspired polydopamine decorated silane modified-electroconductive gelatin-PEDOT:PSS scaffolds for bone regeneration

Adler,

Monavari,

Abraham

et al. 2023

RSC Adv.

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“…Bioactive composite scaffolds are being developed to assist bone regeneration using a variety of materials such as polymers, hydrogels, metals, ceramics, and bio-glasses in order to find the best material with which living tissue will bind [ 71 , 179 , 180 ]. Alternatively, a hydrogel medium mixed with various cell types can be used as bio-inks.…”

Section: Discussionmentioning

confidence: 99%

“…One of the major anticipated advances expected from the ongoing progress in 3DP technology is in the bioprinting of custom individualized grafts, with the capability to manufacture patient-specific organs on demand representing the ultimate goal of the field of 3DP. Currently, bioprinting technology is in its nascency, and only relatively simple prints of bone, cartilage, and skin have seen successful grafting [178] Bioactive composite scaffolds are being developed to assist bone regeneration using a variety of materials such as polymers, hydrogels, metals, ceramics, and bio-glasses in order to find the best material with which living tissue will bind [71,179,180]. Alternatively, a hydrogel medium mixed with various cell types can be used as bio-inks.…”

Section: Bioprintingmentioning

confidence: 99%

The Role of 3D Printing in Planning Complex Medical Procedures and Training of Medical Professionals—Cross-Sectional Multispecialty Review

Meyer-Szary

Luis

Mikulski

et al. 2022

IJERPH

108

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Medicine is a rapidly-evolving discipline, with progress picking up pace with each passing decade. This constant evolution results in the introduction of new tools and methods, which in turn occasionally leads to paradigm shifts across the affected medical fields. The following review attempts to showcase how 3D printing has begun to reshape and improve processes across various medical specialties and where it has the potential to make a significant impact. The current state-of-the-art, as well as real-life clinical applications of 3D printing, are reflected in the perspectives of specialists practicing in the selected disciplines, with a focus on pre-procedural planning, simulation (rehearsal) of non-routine procedures, and on medical education and training. A review of the latest multidisciplinary literature on the subject offers a general summary of the advances enabled by 3D printing. Numerous advantages and applications were found, such as gaining better insight into patient-specific anatomy, better pre-operative planning, mock simulated surgeries, simulation-based training and education, development of surgical guides and other tools, patient-specific implants, bioprinted organs or structures, and counseling of patients. It was evident that pre-procedural planning and rehearsing of unusual or difficult procedures and training of medical professionals in these procedures are extremely useful and transformative.

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“…Compared to alginate-only microspheres (AM), BMP-2 release from the CSM was lower initially but sustained a longer-lasting release profile. The CSM-BMP-2 resulted in increased osteogenic gene expression and an increased BV/TV ratio when compared to AM-BMP-2 and negative controls [ 219 ].…”

Section: Future Directions For Addressing Bone Lossmentioning

confidence: 99%

3D-Printing for Critical Sized Bone Defects: Current Concepts and Future Directions

et al. 2022

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The management and definitive treatment of segmental bone defects in the setting of acute trauma, fracture non-union, revision joint arthroplasty, and tumor surgery are challenging clinical problems with no consistently satisfactory solution. Orthopaedic surgeons are developing novel strategies to treat these problems, including three-dimensional (3D) printing combined with growth factors and/or cells. This article reviews the current strategies for management of segmental bone loss in orthopaedic surgery, including graft selection, bone graft substitutes, and operative techniques. Furthermore, we highlight 3D printing as a technology that may serve a major role in the management of segmental defects. The optimization of a 3D-printed scaffold design through printing technique, material selection, and scaffold geometry, as well as biologic additives to enhance bone regeneration and incorporation could change the treatment paradigm for these difficult bone repair problems.

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A 3D-printed bioactive polycaprolactone scaffold assembled with core/shell microspheres as a sustained BMP2-releasing system for bone repair

Cited by 16 publications

References 38 publications

Mussel-inspired polydopamine decorated silane modified-electroconductive gelatin-PEDOT:PSS scaffolds for bone regeneration

Mussel-inspired polydopamine decorated silane modified-electroconductive gelatin-PEDOT:PSS scaffolds for bone regeneration

The Role of 3D Printing in Planning Complex Medical Procedures and Training of Medical Professionals—Cross-Sectional Multispecialty Review

3D-Printing for Critical Sized Bone Defects: Current Concepts and Future Directions

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