A 3D-Printed, Modular, and Parallelized Microfluidic System with Customizable ECM Integration to Investigate the Roles of Basement Membrane Topography on Endothelial Cells
Abstract:<p>Because dysfunctions of endothelial cells are involved in many
pathologies, <i>in vitro </i>endothelial cell models for pathophysiological and
pharmaceutical studies have been a valuable research tool. Although numerous microfluidic-based
endothelial models have been reported, they had the cells cultured on a flat
surface without considering the possible 3D structure of the native ECM. Endothelial
cells rest on the basement membrane <i>in vivo</i>, which contains an aligned
mic… Show more
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