A 3D-printed nasopharyngeal swab for COVID-19 diagnostic testing

Ford, Jonathan; Goldstein, Todd; Trahan, Sean; Neuwirth, Allison; Tatoris, Kyle; Decker, Summer

doi:10.1186/s41205-020-00076-3

Cited by 67 publications

(51 citation statements)

References 3 publications

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“…Some examples of diagnostic techniques include gene-editing technologies (e.g., CRISPR [ 121 , 122 ]), nanotechnology [ 123 ], smartphone-based tests [ 124 ] and wearable technologies [ 125 ]. The rapid spread of COVID-19 also caused a rise in the use of 3D-printing to address shortages in swabs [ 126 , 127 , 128 ] and other innovative sampling including the use of breath analysis (also known as breathomics [ 129 ]), in a rapid, non-invasive diagnostic solution to detect the virus [ 130 , 131 ]. Whilst these innovative technologies are considered key enablers, there is currently a lack of evidence that provides insights into the scale of their implementation and the outcomes from their adoption, nationally and internationally.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Impact on Diagnostic Innovations: Emerging Trends and Implications

et al. 2021

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Diagnostic testing remains the backbone of the coronavirus disease 2019 (COVID-19) response, supporting containment efforts to mitigate the outbreak. The severity of this crisis and increasing capacity issues associated with polymerase chain reaction (PCR)-based testing, accelerated the development of diagnostic solutions to meet demands for mass testing. The National Institute for Health Research (NIHR) Innovation Observatory is the national horizon scanning organization in England. Since March, the Innovation Observatory has applied advanced horizon scanning methodologies and tools to compile a diagnostic landscape, based upon data captured for molecular (MDx) and immunological (IDx) based diagnostics (commercialized/in development), for the diagnosis of SARS-CoV-2. In total we identified and tracked 1608 diagnostics, produced by 1045 developers across 54 countries. Our dataset shows the speed and scale in which diagnostics were produced and provides insights into key periods of development and shifts in trends between MDx and IDx solutions as the pandemic progressed. Stakeholders worldwide required timely and detailed intelligence to respond to major challenges, including testing capacity and regulatory issues. Our intelligence assisted UK stakeholders with assessing priorities and mitigation options throughout the pandemic. Here we present the global evolution of diagnostic innovations devised to meet changing needs, their regulation and trends across geographical regions, providing invaluable insights into the complexity of the COVID-19 phenomena.

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Section: Discussionmentioning

confidence: 99%

COVID-19 Impact on Diagnostic Innovations: Emerging Trends and Implications

et al. 2021

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“…Other companies all other the world also start designing and printing these swabs like University of South Florida Health in UK joins with Formlabs to print 5000 swabs per day for their hospitals with 3D printers and the team at University of California San Diego with the help Markforged Company design and print 10,000 swabs per day [ 44 ]. The different developers committed to the Open COVID Pledge posted their designs on different platforms like Websites and Github etc [ 45 ].…”

Section: Case Studiesmentioning

confidence: 99%

The rise of 3D Printing entangled with smart computer aided design during COVID-19 era

Nazir

Azhar

Nazir

et al. 2021

Journal of Manufacturing Systems

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Highlights In this article, we present an extensive review on the utilization of 3D printing technology in the days of pandamic. We observe that 3D printing together with smart CAD design show promise to overcome the disruption caused by the lockdown of classical manufacturing units specially for medical and testing equipment, and protective gears. We observe that there are several short communications, commentaries, correspondences, editorials and mini reviews compiled and published; however, a systematic state-of-the-art review is required to identify the significance of 3D printing, design for additive manufacturing (AM), and digital supply chain for handling emergency situations and in the post-COVID era. We present a review of various benefits of 3DP particularly in emergency situations such as a pandemic. Furthermore, some relevant iterative design and 3DP case studies are discussed systematically. Finally, this article highlights the areas that can help to control the emergency situation such as a pandemic, and critically discusses the research gaps that need further research in order to exploit the full potential of 3DP in pandemic and post-pandemic future era.

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“…The model was tested and obtained a 90% match of results taking commercial swabs as golden standard, showing the design is adequate for test. Ford et al [104] designed and developed over 20 nasopharyngeal tips. Their final design showed a 94% concurrence with the current synthetic version in an initial study and multisite clinical trials are currently underway.…”

Section: Nasopharyngeal Swabsmentioning

confidence: 99%

The role of 3D printing during COVID-19 pandemic: a review

et al. 2020

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The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has spread through more than 180 countries, leading to diverse health systems overload around the world. Because of the high number of patients and the supply chain disruption, it generated a shortage of medical devices and personal protective equipment. In this context, initiatives from the additive manufacturing community emerged to fight the lack of devices. Diverse designs were produced and are currently being used in hospitals by patients and health workers. However, as some devices must follow strict standards, these products may not fulfill these standards. Therefore, to ensure the user's health, there is a need for understanding each device, their usage, and standards. This study reviews the use of additive manufacturing during COVID-19 pandemic. It gathers the source of several 3D printed devices such as face shields, face masks, valves, nasopharyngeal swabs, and others, discussing their use and regulatory issues. In this regard, the major drawbacks of the technology, addressed for the next pandemic scenario, are highlighted. Finally, some insights of the future of additive manufacturing during emergency are given and discussed.

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A 3D-printed nasopharyngeal swab for COVID-19 diagnostic testing

Cited by 67 publications

References 3 publications

COVID-19 Impact on Diagnostic Innovations: Emerging Trends and Implications

COVID-19 Impact on Diagnostic Innovations: Emerging Trends and Implications

The rise of 3D Printing entangled with smart computer aided design during COVID-19 era

The role of 3D printing during COVID-19 pandemic: a review

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