A 3D printed pulmonary mock loop for hemodynamic studies in congenital heart disease

Abstract

Background With the increasing survival of the congenital heart disease population, there is a growing need for in-depth understanding of blood circulation in these patients. Mock loops provide the opportunity for comprehensive hemodynamic studies without burden and risks for patients. This study aimed to evaluate the ability of the presented mock loop to mimic the hemodynamics of the pulmonary circulation with and without stenosis and the MR compatibility of the system. Methods A pulsatile pump with two chambers, separated by a flexible membrane, was designed and 3D printed. A cough assist device applied an alternating positive and negative pressure on the membrane. One adult, and three pediatric pulmonary bifurcations were 3D printed and incorporated in the setup. Two pediatric models had a 50% stenosis of the left branch. Bilateral compliance chambers allowed for individual compliance tuning. A reservoir determined the diastolic pressure. Two carbon heart valves guaranteed unidirectional flow. The positive pressure on the cough assist device was tuned until an adequate stroke volume was reached with a frequency of 60 bpm. Flow and pressure measurements were performed on the main pulmonary artery and the two branches. The MR compatibility of the setup was evaluated. Results A stroke volume with a cardiac index of 2L/min/m2 was achieved in all models. Physiological pressure curves were generated in both normal and stenotic models. The mock loop was MR compatible. Conclusion This MR compatible mock loop, closely resembles the pulmonary circulation thereby providing a controllable environment for hemodynamic studies.

A Mock Circulation Loop to Characterize In Vitro Hemodynamics in Human Systemic Arteries with Stenosis

“…By offering safe and effective methods, MCLs allow for the investigation and analysis of the complex hemodynamics of human cardiocirculatory systems. To explore and characterize hemodynamic abnormalities in diseased human arterial circulations, researchers have worked on developing MCLs integrated with 3D-printed patient-specific models of the pulmonary artery [55,56], aorta [57,58], and coronary artery [59,60]. These patient-specific models, created through 3D printing, provide anatomically accurate features for MCLs, enabling precise simulations of the physiological hemodynamics of complex systems.…”