This study proposes an effective method to measure centrosymmetric 3D static and dynamic deformations from the microscale to macroscale using grid method with a single camera. The camera was tilted at a particular angle and used to observe specimen grids in order to acquire coupling fields of both in-plane and out-of-plane displacement. This study also analyzes the decoupling methods of these two displacement types, and a systematic deduction of a theoretical equation for 3D deformation analysis was conducted based on the method. The sensitivity of morphology measurement was then evaluated and the elimination of noise and rotational errors was discussed. The efficiency and accuracy of this technique was verified through a microscale static feasibility test and a highspeed impact experiment that simulated an underwater explosion. The proposed approach uses minimal equipment, is simple and convenient, and can be used to measure centrosymmetric 3D deformation in multi-scale both statically and dynamically. In addition, this method avoids the nonsynchronization problem of a pair of high-speed cameras in high-speed 3D measurements.