A 4 &lt;formula formulatype="inline"&gt;&lt;tex Notation="TeX"&gt;$\mu{\rm W}/{\rm Ch}$&lt;/tex&gt;&lt;/formula&gt; Analog Front-End Module With Moderate Inversion and Power-Scalable Sampling Operation for 3-D Neural Microsystems

Al-Ashmouny, K. M.; Chang, Sun-Il; Yoon, Euisik

doi:10.1109/tbcas.2012.2218105

Cited by 25 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such a probe could, in principle, record from between 1000 to 5000 neurons and determine the three-dimensional position of both cell bodies and the main dendrites of each neuron. These technical improvements are within reach but will require high-density off-chip lead transfers, probably in conjunction with on-probe circuitry ( Al-Ashmouny et al, 2012 ; Bai and Wise, 2001 ; Perlin and Wise, 2010 ; Wise et al, 2004 ). We should emphasize that even slim-shank probes come at the expense of tissue damage, fractional displacement volume and associated disruption of physiological activity that needs to be carefully investigated ( Claverol-Tinture and Nadasdy, 2004 ; Polikov et al, 2005 ; Tsai et al, 2009 )…”

Section: Hardware Components For Large-scale Monitoring Of Neuronal Amentioning

confidence: 99%

Tools for Probing Local Circuits: High-Density Silicon Probes Combined with Optogenetics

Buzsáki

Stark

Berényi

et al. 2015

Neuron

298

229

View full text Add to dashboard Cite

To understand how function arises from the interactions between neurons, it is necessary to use methods that allow the monitoring of brain activity at the single-neuron, single-spike level and the targeted manipulation of the diverse neuron types selectively in a closed-loop manner. Large-scale recordings of neuronal spiking combined with optogenetic perturbation of identified individual neurons has emerged as a suitable method for such tasks in behaving animals. To fully exploit the potential power of these methods, multiple steps of technical innovation are needed. We highlight the current state-of-the-art in electrophysiological recording methods, combined with optogenetics, and discuss directions for progress. In addition, we point to areas where rapid development is in progress and discuss topics where near-term improvements are possible and needed.

show abstract

Section: Hardware Components For Large-scale Monitoring Of Neuronal Amentioning

confidence: 99%

Tools for Probing Local Circuits: High-Density Silicon Probes Combined with Optogenetics

Buzsáki

Stark

Berényi

et al. 2015

Neuron

298

229

View full text Add to dashboard Cite

show abstract

“…This strategy leverages the fact that not all electrode sites may provide useful information after implantation [97, 101, 145] or that the necessary information can be obtained from a small subset of electrodes, although the useful electrode subset is not known a priori [118]. For example, Al-ashmouny et al reported a 128-input channel neural recording IC [2] with only 16 inputs selectively routed to the front-end amplifiers, therefore achieving power and area reduction. Another recent work by Lopez et al [77] adopted the same method and multiplexed 455 electrode inputs to 52 amplifiers.…”

Section: Background On Neural Recording Amplifiersmentioning

confidence: 99%

“…The front-end amplifiers operated at 1.8 V, while the supply voltage of the ADC and the backend digital blocks were reduced to 1 V to decrease the dynamic switching power. Similarly, Al-ashmouny et al [2] reported an implementation where the supply voltage of the ADC was made scalable according to the sampling rate, throttling the power consumption. Finally, the chip reported by Han et al [48] used 0.9 and 0.45 V supply domains for the amplification stage and ADC, respectively.…”

Section: Background On Neural Recording Amplifiersmentioning

confidence: 99%

Implantable neurotechnologies: a review of integrated circuit neural amplifiers

Greenwald

et al. 2016

Med Biol Eng Comput

View full text Add to dashboard Cite

Neural signal recording is critical in modern day neuroscience research and emerging neural prosthesis programs. Neural recording requires the use of precise, low-noise amplifier systems to acquire and condition the weak neural signals that are transduced through electrode interfaces. Neural amplifiers and amplifier-based systems are available commercially or can be designed in-house and fabricated using integrated circuit (IC) technologies, resulting in very large-scale integration or application-specific integrated circuit solutions. IC-based neural amplifiers are now used to acquire untethered/portable neural recordings, as they meet the requirements of a miniaturized form factor, light weight and low power consumption. Furthermore, such miniaturized and low-power IC neural amplifiers are now being used in emerging implantable neural prosthesis technologies. This review focuses on neural amplifier-based devices and is presented in two interrelated parts. First, neural signal recording is reviewed, and practical challenges are highlighted. Current amplifier designs with increased functionality and performance and without penalties in chip size and power are featured. Second, applications of IC-based neural amplifiers in basic science experiments (e.g., cortical studies using animal models), neural prostheses (e.g., brain/nerve machine interfaces) and treatment of neuronal diseases (e.g., DBS for treatment of epilepsy) are highlighted. The review concludes with future outlooks of this technology and important challenges with regard to neural signal amplification.

show abstract

±0.18‐V supply voltage gate‐driven PGA with 0.7‐Hz to 2‐kHz constant bandwidth and 0.15‐μW power dissipation

Pourashraf

Ramírez-Angulo

López-Martín

et al. 2017

Circuit Theory & Apps

View full text Add to dashboard Cite

A simple gate-driven scheme to reduce the minimum supply voltage of AC coupled amplifiers by close to a factor of two is introduced. The inclusion of a floating battery in the feedback loop allows both input terminals of the op-amp to operate very close to a supply rail. This reduces essentially supply requirements. The scheme is verified experimentally with the example of a PGA that operates with ±0.18-V supply voltages in 0.18-μm CMOS technology and a power dissipation of about 0.15 μW. It has a 4-bit digitally programmable gain and 0.7-Hz to 2-kHz true constant bandwidth that is independent on gain with a 25-pF load capacitor. In addition, simulations of the same circuit in 0.13-μm CMOS technology show that the proposed scheme allows operation with ±0.08-V supplies, 7.5-Hz to 8-kHz true constant bandwidth with a 25-pF load capacitor, and a total power dissipation of 0.07 μW. KEYWORDS floating battery, low voltage amplifier, nanowatt power consumption, programmable gain amplifier, true constant bandwidth | INTRODUCTIONA crucial aspect to reduce the power dissipation of analog and digital integrated systems is the reduction of their minimum supply requirements. For analog circuits based on op-amps, this can be achieved by keeping both amplifier input terminals close to a supply rail. Several papers have reported systems operating from supplies as low as 0.5 V (some without experimental verification). Most of them are bulk-driven (BD) circuits based on injecting input signals through the bulk terminal while connecting the gate to a supply rail 1-7 . The main disadvantage of the BD technique is that bulk transconductance is usually a factor 4-5 lower than the gate transconductance. This leads to essential gain bandwidth degradation, higher input noise, higher offset, etc. Also, input leakage currents (required to be supplied by the signal sources) can become comparable to the bias currents even for moderate input signal swings that weakly turn on the bulk PN junction. Additionally bulk driven circuits suffer from large bulk parasitic capacitances that results in large input capacitance. Other non-body driven (gate-driven (GD)) low voltage approaches use relatively large valued DC current sources to maintain both inputs of the op-amp close to a supply rail. The DC current sources are implemented with relatively low valued resistors. They increase essentially quiescent power dissipation and can also lead to a large output offset voltage and bandwidth degradation 7 . In this paper, we introduce a very simple technique to implement GD AC coupled amplifiers that can operate with ±0.18-V dual supply voltages V supply in 0.18-μm CMOS technology and ±0.08 V in 0.13-μm CMOS technology.

show abstract

A 4 <formula formulatype="inline"><tex Notation="TeX">$\mu{\rm W}/{\rm Ch}$</tex></formula> Analog Front-End Module With Moderate Inversion and Power-Scalable Sampling Operation for 3-D Neural Microsystems

Cited by 25 publications

References 34 publications

Tools for Probing Local Circuits: High-Density Silicon Probes Combined with Optogenetics

Tools for Probing Local Circuits: High-Density Silicon Probes Combined with Optogenetics

Implantable neurotechnologies: a review of integrated circuit neural amplifiers

±0.18‐V supply voltage gate‐driven PGA with 0.7‐Hz to 2‐kHz constant bandwidth and 0.15‐μW power dissipation

Contact Info

Product

Resources

About