Piezoresistive acceleration sensors are widely used in various fields of the industrial Internet of Things because of their lightweight, fast response, and small size. The structural sensitivity of the sensor affects the accuracy of the measurement. And the sensitivity that the traditional method designs are only a feasible solution, not an optimal solution. Due to the differences in factory processes, the optimization of structural sensitivity is an NP-hard problem. To solve the design problem of structural sensitivity, we adopt the swarm intelligence algorithm in this paper, and we design a model for the structural sensitivity of the piezoresistive acceleration sensor. In addition, an improved grasshopper optimization algorithm (CC-GOA) that combines chaos strategy and Cauchy mutation is proposed to optimize the structural sensitivity of the piezoresistive acceleration sensor, and the structure of the sensor is composed of four beams and mass block. The experiments are compared with six well-known algorithms on 16 benchmark functions to verify the algorithm performance of CC-GOA, and then, the structural sensitivity of the piezoresistive acceleration sensor is optimized by CC-GOA. The results indicate that the piezoresistive acceleration sensor is designed with high sensitivity and superiority.