A 5 Years Study on Histomorphology and Metaplastic Changes in the Gallbladder in a Tertiary Care Hospital

Abstract

A BS T R A C T BACKGROUNDGallbladder is among the most commonly surgically resected organ and the number of cholecystectomies has increased by more than 50% in the past decade. Cholecystitis is the most common disease of the gallbladder. It is the frequent cause of morbidity in many patients. It also affects a significant portion of the world's population. Over 95% of biliary tract disease is attributable to cholelithiasis. Chronic cholecystitis is the major indication for cholecystectomy. METHODSThis is a 5 years retrospective study carried out in the cholecystotomy specimens received in the Dept. of Pathology, RIMS during the period of 2010 to 2015. RESULTSA total of 4964 cholecystectomy specimen received in the Dept. of Pathology were analysed. Histomorphological diagnosis along with changes in the gallbladder epithelium were noted. 2432 cases (49%) show pyloric metaplasia and 447 cases (9%) show intestinal metaplasia. The mean age for pyloric metaplasia is 45 years and 56 years for intestinal metaplasia. There were 3 (0.06%) incidental diagnosis of gallbladder adenocarcinoma. CONCLUSIONSCholecystitis can be regarded as a disease of the modern times. Cholecystectomy, today is second only to appendicectomy. Pyloric metaplasia is the predominant epithelial change encountered in this study followed by intestinal metaplasia.