A 50-Year-old With Gross Hematuria

Szymanski, Linda J.; Szymanski, James; Muhletaler, Fred; Alassi, Osama

doi:10.1016/j.urology.2012.04.028

Cited by 2 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…What appears to perpetuate this uncertainty is that CCA is often found with a variety of other tissue forms. For example, our case report found associated urothelial CIS, where as Szymanski [3] reported CCA with surrounding endometriosis. The most recent pathological study by Sung [11] of twelve cases using immunohistochemical and molecular genetic appraisal with fluorescence in situ hybridization reported it to be of urological origin.…”

Section: Discussionmentioning

confidence: 57%

See 1 more Smart Citation

Primary Clear Cell Adenocarcinoma in a Female Urethral Diverticulum: A Case Report and Review

Sheahan¹

2013

World J Nephrol Urol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 57%

“…Clear cell adenocarcinoma is a rare variant of adenocarcinoma of the urinary tract with approximately 100 case reports to date of which 40 are bladder cases [2,3]. As mentioned before it was first characterised in 1968 by Dow and Young [1], with the first urethral case in 1973 by Konnak [4].…”

Section: Discussionmentioning

confidence: 99%

Primary Clear Cell Adenocarcinoma in a Female Urethral Diverticulum: A Case Report and Review

Sheahan¹

2013

World J Nephrol Urol

View full text Add to dashboard Cite

show abstract

Clear Cell Adenocarcinoma in Men

Grosser¹,

Matoso

Epstein

2020

American Journal of Surgical Pathology

View full text Add to dashboard Cite

Clear cell adenocarcinoma (CCA) is a rare tumor in the genitourinary tract with female predominance and few reports in men. We identified 15 cases of CCA in men evaluated at our institution. Five arose in the bladder, 7 in the prostate or prostatic urethra, 2 in the membranous urethra (1 multifocal in the prostatic and membranous urethra), 1 periprostatic (likely from an embryologic remnant), and 1 between rectum and bladder (likely in a prostatic utricle cyst). No cases showed associated Müllerian structures. One case showed separate foci of nephrogenic adenoma at diagnosis, and 1 case showed urothelial carcinoma in situ on a later follow-up biopsy. Four tumors extended into other organs (prostate to seminal vesicle and periprostatic soft tissue, periprostatic soft tissue to prostate, prostatic urethra to bladder and rectum, and prostate to bladder neck). One tumor showed extraprostatic extension alone. Four tumors metastasized to lymph nodes, with 3 also metastasizing to other sites (bladder, lung and adrenal, and right flank). Eleven patients underwent resection, including 3 transurethral resections. Seven underwent other treatments, including radiation (5 [1 for recurrence]), chemotherapy (3), hormonal therapy (3), immunotherapy with nivolumab (1), and targeted therapy with gefitinib (1). The mean follow-up was 35 months (range: 1 to 138 mo). At the last follow-up, 7 patients showed no evident disease and 3 were alive with disease. Four died with the cause of death unknown, with 2 cases having confirmed disease at the time of death and the remaining 2 dying less than a year after diagnosis. The mean time to death was 16 months (range: 6 to 39 mo). No follow-up was available on 1 patient. All patients who died in this series had CCA of the prostate or prostatic urethra. Pathologists need to be attuned to CCA occurring in males, given that the literature emphasizes its occurrence in females. In addition to established sites such as bladder and urethra, our series demonstrates that tumor may present in unusual adjacent sites, such as in periprostatic embryologic remnants or prostatic utricle.

show abstract

A 50-Year-old With Gross Hematuria

Cited by 2 publications

References 13 publications

Primary Clear Cell Adenocarcinoma in a Female Urethral Diverticulum: A Case Report and Review

Primary Clear Cell Adenocarcinoma in a Female Urethral Diverticulum: A Case Report and Review

Clear Cell Adenocarcinoma in Men

Contact Info

Product

Resources

About