A 55‐year‐old woman with orbital inflammation

Schwab, Pascale; Harmon, David C.; Bruno, Richard L.; Fraunfelder, Frederick W.; Kim, Donna Hyunchung

doi:10.1002/acr.21822

Cited by 10 publications

(2 citation statements)

References 39 publications

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“…Some suggest that γδ T cells play a role in triggering the in ammatory cascade by releasing interleukin-1 and interleukin-6. 29,30 The role of previous allergic or anaphylactic reactions is not understood.…”

Section: Discussionmentioning

confidence: 99%

Zoledronic Acid-Induced Orbital Inflammatory Disease

veisi,

piryaiee,

tahavvori

2024

Preprint

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Bisphosphonates are a group of drugs that are used to prevent the loss of bone density and treat osteoporosis and similar bone diseases. Zoledronate (zolenedronic acid) has been increasingly used because of its advantages of intravenous infusion and annual regimens. Here, we present a case of zolendronic acid-related diffuse orbital inflammation. A 67-year-old woman with a history of breast cancer and chemotherapy developed severe unilateral orbital and periorbital swelling approximately 8 hours after receiving her first zoledronate infusion. In this case, the interval between infusion and the beginning of the symptoms was too short compared with most other reported similar cases. Her signs and symptoms relapsed 4 days after discontinuation of the short course of systemic steroid therapy. Orbital inflammation improved after systemic corticosteroid therapy was restarted, but the patient did not relapse following discontinuation of the drug in a tapering manner.

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Section: Discussionmentioning

confidence: 99%

Zoledronic Acid-Induced Orbital Inflammatory Disease

veisi,

piryaiee,

tahavvori

2024

Preprint

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“…The HORIZON-Pivotal Fracture Trial reported eye pain in 0.2% (zero in controls) and eye inflammation in 0.4% (0.1% in controls) in patients receiving bisphosphonates [6]. As has been documented in several case reports, ocular inflammation following bisphosphonate use can involve almost any part of the eye like proptosis, periorbital edema, extraocular muscle involvement, orbital fat involvement, myositis, scleritis, uveitis, and optic neuritis [7][8][9][10][11][12][13][14][15][16]. A cohort analysis by Pazianas et al suggested that the presence of basal inflammation may predispose to the development of orbital inflammation following bisphosphonates [17].…”

Section: Discussionmentioning

confidence: 99%

Acute Iridocyclitis Associated With Intravenous Zoledronic Acid: A Case Report

Ankireddypalli¹,

Sibley²

2023

Cureus

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Bisphosphonates are widely used drugs for the management of osteoporosis. Intravenous (IV) zoledronic acid (ZA) is frequently prescribed in cases of oral bisphosphonate intolerance or non-compliance. Well-known immediate ZA side effects include flu-like symptoms such as nausea, myalgias, bone and joint pains, and fever. Here we report a case of a rare side effect of acute anterior uveitis following initial dosing of ZA in a 71-year-old female with osteoporosis who had been vitamin D deficient a couple of months earlier. She presented with headache, bilateral eye redness, and pain post ZA infusion. Findings of diffuse conjunctival injection, and flare with cells in the anterior chamber were suggestive of anterior uveitis. Her symptoms resolved with prednisolone eye drops in three weeks. Ocular inflammation is a rare but serious side effect of this commonly administered drug. Optimizing vitamin D levels prior to treatment may help to prevent this condition. Clinicians should be aware of the rare occurrence of post-ZA ocular inflammation. Early recognition and prompt treatment are essential.

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Bisphosphonate-induced orbital inflammation: more common than once thought?

Curragh

Selva

2019

Osteoporos Int

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A 55‐year‐old woman with orbital inflammation

Cited by 10 publications

References 39 publications

Zoledronic Acid-Induced Orbital Inflammatory Disease

Zoledronic Acid-Induced Orbital Inflammatory Disease

Acute Iridocyclitis Associated With Intravenous Zoledronic Acid: A Case Report

Bisphosphonate-induced orbital inflammation: more common than once thought?

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