A 6‐year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder

Voshaar, Richard C. Oude; Dimitriadis, Menelaos; vandenBrink, Rob H. S.; Aprahamian, Ivan; Borges, Marcus Kiiti; Marijnissen, Radboud M.; Hoogendijk, Emiel O.; Rhebergen, Didi; Jeuring, Hans W.

doi:10.1002/gps.5588

Cited by 25 publications

(15 citation statements)

References 44 publications

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“…The studies listed in Table 1 represent those on frailty trajectories in older populations. However, in the field of frailty trajectories, more specific research directions are evolving, such as work in specific patient populations (e.g., psychiatry and oncology), 41 , 42 ) latent frailty trajectories (i.e., groupings of people based on distinct frailty trajectories), 43 ) frailty fluctuations (i.e., within-person deviations from general frailty trajectories), 10 ) the order in which frailty components develop, 44 ) and terminal decline in frailty. 45 , 46 )…”

Section: Changes In Frailtymentioning

confidence: 99%

Trajectories, Transitions, and Trends in Frailty among Older Adults: A Review

Hoogendijk

Dent

2022

Ann Geriatr Med Res

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Frailty is an age-related clinical state associated with deterioration across multiple physiological systems and a leading cause of morbidity and mortality later in life. To understand how frailty develops and what causes its progression, longitudinal data with repeated frailty measurements are required. This review summarizes evidence from longitudinal studies on frailty trajectories, transitions, and trends. We identified several consistent findings: frailty increases with aging and is a dynamic condition, and more recent generations of older adults have higher frailty levels. These findings have both clinical and public health relevance, including the provision of health-and aged care services in the coming years. Further studies are required, particularly those conducted in low-and middleincome countries and those investigating factors associated with changes in frailty. The latter may help develop better-targeted interventions to reverse or slow the progression of frailty.

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Section: Changes In Frailtymentioning

confidence: 99%

Trajectories, Transitions, and Trends in Frailty among Older Adults: A Review

Hoogendijk

Dent

2022

Ann Geriatr Med Res

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“… 37 , 38 Yet, using data of the Netherlands Study of Depression in Older persons (NESDO), we showed that frailty at baseline was highly predictive of premature mortality among depressed older patients, irrespective whether frailty was operationalized according to the frailty phenotype criteria 39 or the deficits accumulation model underlying the frailty index. 40 In sum, these studies support the (predictive) validity of frailty assessment in depression and thus for risk stratification in geriatric mental health care. In the second part of this review, implications for treatment will be discussed.…”

Section: Epidemiologymentioning

confidence: 54%

The Frail Depressed Patient: A Narrative Review on Treatment Challenges

Aprahamian¹,

Borges²,

Hanssen³

et al. 2022

CIA

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Although the public importance of frailty is widely acknowledged by the World Health Organization, physical frailty is still largely neglected in geriatric mental health care. Firstly in this narrative review, we summarize the knowledge on the epidemiology of the association between depression and frailty, whereafter implications for treatment will be discussed. Even though frailty and depression have overlapping diagnostic criteria, epidemiological studies provide evidence for distinct constructs which are bidirectionally associated. Among depressed patients, frailty has predictive validity being associated with increased mortality rates and an exponentially higher fall risk due to antidepressants. Nonetheless, guidelines on the treatment of depression neither consider frailty for risk stratification nor for treatment selection. We argue that frailty assessment enables clinicians to better target the pharmacological and psychological treatment of depression as well as the need for interventions targeting primarily frailty, for instance, lifestyle interventions and reduction of polypharmacy. Applying a frailty informed framework of depression treatment studies included in a meta-analysis reveals that the benefit–harm ratio of antidepressants given to frail depressed patients can be questioned. Nonetheless, frail-depressed patients should not withhold antidepressants as formal studies are not available yet, but potential adverse effects should be closely monitored. Dopaminergic antidepressants might be preferable when slowness is a prominent clinical feature. Psychotherapy is an important alternative for pharmacological treatment, especially psychotherapeutic approaches within the movement of positive psychology, but this approach needs further study. Finally, geriatric rehabilitation, including physical exercise and nutritional advice, should also be considered. In this regard, targeting ageing-related abnormalities underlying frailty that may also be involved in late-life depression such as low-grade inflammation might be a promising target for future studies. The lack of treatment studies precludes firm recommendations, but more awareness for frailty in mental health care will open a plethora of alternative treatment options to be considered.

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“…A study in US women also applied reduced rank regression (using CRP, IL-6 and TNF-A as response variables) and found that higher scores in inflammatory dietary patterns, including sugary beverages, refined grains, red meat, dietary soft drinks, margarine, and other vegetables and fish, were associated with higher depressive symptoms. In addition, three studies using prior DII observed a statistically significant positive association between higher DII scores and higher depressive symptoms 28 29…”

Section: Discussionmentioning

confidence: 99%

Association of Dietary Inflammatory Index (DII) and depression in the elderly over 55 years in Northern China: analysis of data from a multicentre, cohort study

Zhan

Huang

et al. 2022

BMJ Open

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ObjectivesOur study aimed to assess the association between the Dietary Inflammatory Index (DII) and depression in the elderly over 55 years in Northern China.MethodsWe analysed the data of 2022 Chinese adults aged 55 and over from a community-based neurological disease cohort study from 2018 to 2019. A validated semiquantitative food frequency questionnaire was used to assess eating habits at the time of inclusion. Multiple logistic regression was used for analysis, and social demographics, lifestyle and health-related factors were adjusted.ResultsAmong the included population, the prevalence of depression was 23.39%. Mean (SD) and range of the DII in the included population were 1.70 (1.42) and −5.20 to +5.68. The risk of depression was significantly higher in participants in the most pro-inflammatory group (quartile 4) than in the participants in the most anti-inflammatory group (quartile 1) (OR 1.53; 1.37 to 1.82; p-trend=0.01). The subgroup analysis of body mass index (BMI) showed that there is a significant association between DII and the risk of depression in overweight and obese people (p＜0.05). The restricted cubic spline results show that the OR value of depression possesses an upward trend with the increase of the DII score.ConclusionsAged patients with depression present a higher potential for dietary inflammation. Pro-inflammatory diets might increase the risk of depressive symptoms. Further research in different populations is crucial to confirm the association between DII and depression.

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A 6‐year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder

Cited by 25 publications

References 44 publications

Trajectories, Transitions, and Trends in Frailty among Older Adults: A Review

Trajectories, Transitions, and Trends in Frailty among Older Adults: A Review

The Frail Depressed Patient: A Narrative Review on Treatment Challenges

Association of Dietary Inflammatory Index (DII) and depression in the elderly over 55 years in Northern China: analysis of data from a multicentre, cohort study

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