A 66-Year-Old Man With an Abdominal Aortic Aneurysm

Schermerhorn, Marc L.

doi:10.1001/jama.2009.1502

Cited by 40 publications

(27 citation statements)

References 90 publications

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“…2,7,37 Chronic smoke exposure is also associated with substantial increase in progression of aneurysmal dilatation in a mouse model. 38 Conversely, smoking cessation apparently reduces the growth rate of small AAAs in patients with AAA.…”

Section: Downloaded Frommentioning

confidence: 99%

“…[2][3][4][5][6] AAA is clinically diagnosed as either a 1.5-fold increase in aortic diameter compared with normal adjacent aorta or an aneurysm with a diameter exceeding 30 mm. 7 AAA usually shows slow progression, but the condition tends to be asymptomatic until the time of aortic rupture. The overall mortality rate for patients with ruptured AAAs exceeds 80%, and about half of the deaths attributed to rupture occur before the patient reaches the surgical room.…”

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confidence: 99%

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Macrophage-Derived Angiopoietin-Like Protein 2 Accelerates Development of Abdominal Aortic Aneurysm

Tazume¹,

Miyata²,

Tian³

et al. 2012

ATVB

102

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Objective-Recently, we reported that angiopoietin-like protein 2 (Angptl2) functions in various chronic inflammatory diseases. In the present study, we asked whether Angptl2 and its associated chronic inflammation contribute to abdominal aortic aneurysm (AAA). Methods and Results-Immunohistochemistry revealed that Angptl2 is abundantly expressed in infiltrating macrophages within the vessel wall of patients with AAA and in a CaCl 2 -induced AAA mouse model. When Angptl2-deficient mice were used in the mouse model, they showed decreased AAA development compared with wild-type mice, as evidenced by reduction in aneurysmal size, less severe destruction of vessel structure, and lower expression of proinflammatory cytokines and matrix metalloproteinase-9. However, no difference in the number of infiltrating macrophages within the aortic aneurysmal vessel wall was observed between genotypes. AAA development was also significantly suppressed in wild-type mice that underwent Angptl2-deficient bone marrow transplantation. Expression levels of proinflammatory cytokines and metalloproteinase-9 in Angptl2-deficient macrophages were significantly decreased, and those decreases were rescued by treatment of Angptl2 deficient macrophages with exogenous Angptl2. Key Words: abdominal aortic aneurysm n angiopoietin-like protein 2 n chronic inflammation n macrophage n matrix metalloproteinase Conclusions-Macrophage-derived

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Section: Downloaded Frommentioning

confidence: 99%

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confidence: 99%

Macrophage-Derived Angiopoietin-Like Protein 2 Accelerates Development of Abdominal Aortic Aneurysm

Tazume¹,

Miyata²,

Tian³

et al. 2012

ATVB

102

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“…Abdominal Aortic Aneurysm (AAA) is defined as a localized and permanent dilatation of the abdominal aorta, beyond 50% of the normal aorta diameter (Schermerhorn, 2009). The prevalence of AAA ranges from 1.3% to 8.9% in men and 1% to 2.2% in women (Sakalihasan et al, 2005;Singh et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Abdominal Aortic Aneurysm in Patients with Coronary Artery Disease: A Review Article

Elkalioubie¹,

Jude²,

Dupont³

2011

Diagnosis and Treatment of Abdominal and Thoracic Aortic Aneurysms Including the Ascending Aorta and the Aortic Arch

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“…Appropriate patient selection and timing of intervention are essential. In patients who need emergency surgery for aortic aneurysm rupture, the mortality is 50% among the patients who reach the hospital, compared to 1% to 5% for elective AAA repair (34).…”

Section: Indication For Repairmentioning

confidence: 99%

Current status of the treatment of infrarenal abdominal aortic aneurysms

Wang¹,

Prabhakar²,

Kwolek³

2018

Cardiovasc. Diagn. Ther.

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Aortic aneurysms are the 13 th leading cause of death in the United States. While aneurysms can occur along the entire length of the aorta, the infrarenal location is the most common. Targeted ultrasound screening has been found to be an effective and economical means of preventing aortic aneurysm rupture.The indication for repair includes either symptomatic aneurysms or aneurysms with a diameter greater than

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A 66-Year-Old Man With an Abdominal Aortic Aneurysm

Cited by 40 publications

References 90 publications

Macrophage-Derived Angiopoietin-Like Protein 2 Accelerates Development of Abdominal Aortic Aneurysm

Macrophage-Derived Angiopoietin-Like Protein 2 Accelerates Development of Abdominal Aortic Aneurysm

Abdominal Aortic Aneurysm in Patients with Coronary Artery Disease: A Review Article

Current status of the treatment of infrarenal abdominal aortic aneurysms

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