A 70-Year-Old Woman With Acute Renal Failure

Pitman, Sean D.; Wang, Jun; Serros, Edward R.; Zuppan, Craig W.

doi:10.5858/2006-130-1077-aywwar

Cited by 16 publications

(1 citation statement)

References 4 publications

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“…Gaucher's disease, a histiocytic storage disease, needs to be assessed as a differential diagnosis, especially when histiocytes with crystallized material are found in the bone marrow [75,85]. Gaucher's disease is a metabolic storage disease that resembles the needlelike accumulation of immunoglobulins in the cytoplasm of histiocytes in CSH, with fine cytoplasmic striations caused by the accumulation of glucocerebroside.…”

Section: Discussionmentioning

confidence: 99%

Immunoglobulin-Storing Histiocytosis: A Case Based Systemic Review

Wiese-Hansen

Leh

Hemsing

et al. 2021

JCM

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Crystal-storing histiocytosis (CSH) is a rare event in disorders associated with monoclonal gammopathy and is mostly associated with the accumulation of immunoglobulins (Igs) in the cytoplasm of histiocytes. In this article, we present a case of a 75-year-old female with IgG kappa monoclonal gammopathy of undetermined significance (MGUS) and signs of a non-crystallized version of immunoglobulin-storing histiocytosis (IgSH) in a vertebra corpus. Furthermore, we performed a literature review based on all cases of storing histiocytosis identified by literature search between 1987 and 2020 and identified 140 cases in total. The median age at diagnosis was 60 years (range 18–91), with an equal sex distribution (51% men). The majority of the patients had an underlying neoplastic B-cell disorder, most often multiple myeloma (MM), MGUS, or lymphoplasmacytic lymphoma (LPL). The main affected organ systems or tissue sites were bone (n = 52), followed by head and neck (n = 31), kidney (n = 23), lung (n = 20), and gastrointestinal (GI)-tract (n = 18). IgG was the main immunoglobulin class involved, and most cases were associated with kappa light chain expression. We conclude that IgSH is a rare disease entity but should be considered with unusual findings in several organ systems associated with monoclonal gammopathy, especially with kappa light chain expression.

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Section: Discussionmentioning

confidence: 99%

Immunoglobulin-Storing Histiocytosis: A Case Based Systemic Review

Wiese-Hansen

Leh

Hemsing

et al. 2021

JCM

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Pulmonary crystal‐storing histiocytosis diagnosed by computed tomography‐guided fine‐needle aspiration

Todd

Benninghoff

Frauenhoffer

et al. 2009

Diagnostic Cytopathology

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Crystal-storing histiocytosis (CSH) is a rare process most often occurring in conjunction with an underlying hematopoietic neoplasm, usually multiple myeloma or low-grade B-cell lymphoma. We report the first case of pulmonary CSH diagnosed by fine-needle aspiration biopsy. A patient with a history of urothelial carcinoma developed a lung nodule, which was evaluated by fine-needle aspiration biopsy. Cytologic examination revealed macrophages with abundant cytoplasmic crystals diagnostic of CSH. Based on this cytologic interpretation, additional clinical laboratory evaluation was pursued and revealed a previously unknown monoclonal serum protein. CSH must be differentiated from other non-neoplastic and neoplastic lesions and when diagnosed, should trigger a search for an underlying lymphoproliferative disorder.

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Tumor-like Conditions and Benign Tumors of the Lung

Weissferdt

Moran

2012

Diagnostic Pathology of Pleuropulmonary Neoplasia

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A 70-Year-Old Woman With Acute Renal Failure

Cited by 16 publications

References 4 publications

Immunoglobulin-Storing Histiocytosis: A Case Based Systemic Review

Immunoglobulin-Storing Histiocytosis: A Case Based Systemic Review

Pulmonary crystal‐storing histiocytosis diagnosed by computed tomography‐guided fine‐needle aspiration

Tumor-like Conditions and Benign Tumors of the Lung

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