A 90-day toxicology study of high-amylose transgenic rice grain in Sprague–Dawley rats

Zhou, Xing; Dong, Ying; Xiao, Xiang; Wang, Yun; Xu, Yong; Xu, Bin; Shi, Wei; Zhang, Yi; Zhu, Li Jia; Liu, Qiaoquan

doi:10.1016/j.fct.2011.09.024

Cited by 51 publications

(32 citation statements)

References 35 publications

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“…Based on this principle, a comparison of nutritional components between the GM crop and their parents is a very important factor in the GM food or feed product safety evaluation (OECD, 1993;He et al, 2009;Zhou et al, 2011;Park et al, 2012;Wang et al, 2013). In our study, the safety of long-term (at least 195-day) dietary exposure to GM GTS40-3-2 herbicide-resistant soybean was assessed by nutritional response and standard toxicological variables in SD rats.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, the ''substantial equivalence'' principle has been considered as a food safety evaluation international standard of GM crops (Han et al, 2005;He et al, 2009;Zhou et al, 2011;Wang et al, 2013). Based on this principle, a comparison of nutritional components between the GM crop and their parents is a very important factor in the GM food or feed product safety evaluation (OECD, 1993;He et al, 2009;Zhou et al, 2011;Park et al, 2012;Wang et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

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Toxicologic evaluation of chronic feeding of glyphosate-resistant transgenic soybean GTS40-3-2 meal to rats

et al. 2017

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To assess the safety of glyphosate-resistant transgenic soybean, the transgenic soybean GTS40-3-2 meal and its non-transgenic counterpart parent A5403 were fed to first- and second-generation Sprague-Dawley (SD) rats (Rattus norvegicus) for 195 days. The soybean meal made up 20% of the total weight of the feed. Body weight, food consumption, hematology, blood biochemistry, and pathological observations were monitored weekly. The results showed that rats of each group experienced good growth and development, and although results of some organ weight ratios and serum biochemistry between the groups were significantly different (P<0.05), they were of no biological significance because the variations were within the normal range. These results indicate that glyphosate-resistant transgenic soybean GTS40-3-2 meal is as safe as its non-transgenic parent soybean A5403 in a long-term SD rat feeding study. The study provides experimental evidence for the safe usage of transgenic soybean GTS40-3-2.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Toxicologic evaluation of chronic feeding of glyphosate-resistant transgenic soybean GTS40-3-2 meal to rats

et al. 2017

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“…Although outside the scope of this literature review, the literature describes other studies of exposure to DvSnf7 dsRNA by different insects, including honey bee, with no apparent observed adverse effects reportedTan et al, 2016).High-amylose transgenic rice was generated using antisense RNA inhibition of starch branching enzymes, which produce resistant starch granules(Wei et al, 2010) with the potential to improve the large bowel health or blood glucose in rats. Minor changes between rats given control diet and the rice diet were observed for certain sexes in some serum chemistry parameters including ALKP or cholesterol, but were not considered biologically significant or attributable to the transgenic rice(Zhou et al, 2011). No differences in body weight, food consumption, haematological parameters, organ weight, or urine analysis were found among the three groups(Zhou et al, 2011).…”

mentioning

confidence: 91%

“…A 90-day toxicology study was performed in Sprague-Dawley rats fed with diets containing 70% of either transgenic rice line flour, its nearisogenic rice flour or the control diet (n=10 rats per sex per group). The authors concluded that subchronic consumption of diets from transgenic rice does not cause adverse effects in rats(Zhou et al, 2011). Minor changes between rats given control diet and the rice diet were observed for certain sexes in some serum chemistry parameters including ALKP or cholesterol, but were not considered biologically significant or attributable to the transgenic rice(Zhou et al, 2011).…”

mentioning

confidence: 98%

“…µg/g of tissue on a dry weight basis. No differences in body weight, food consumption, haematological parameters, organ weight, or urine analysis were found among the three groups(Zhou et al, 2011). A 90-day toxicology study was performed in Sprague-Dawley rats fed with diets containing 70% of either transgenic rice line flour, its nearisogenic rice flour or the control diet (n=10 rats per sex per group).…”

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confidence: 99%

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Literature review of baseline information on non‐coding RNA (ncRNA) to support the risk assessment of ncRNA‐based genetically modified plants for food and feed

Dávalos

Henriques

Latasa

et al. 2019

EFS3

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This report is the outcome of an EFSA procurement (NP/EFSA/GMO/2016/01) reviewing relevant scientific information on ncRNA and on RNA interference (RNAi) that could support the food and feed risk assessment of ncRNA-based genetically modified (GM) plants. Information was retrieved through key words and key questions covering the stability and degradation of ncRNAs after oral ingestion, the passage of ncRNAs from food and feed to human and animal organs and tissues via the gastrointestinal tract and other barriers, as well as the potential effects on the gastrointestinal tract, the immune system or the entire organism. Full description of the strategy used for the literature search and for studies selection is provided and the number of retrieved publications is reported. This report is divided into four parts discussing the kinetics of exogenous ncRNAs in humans and animals, with focus on ingested ncRNAs (Part 1); the possible effects of ncRNAs on the gastrointestinal tract (Part 2), systemically (Part 3) and on the immune system (Part 4). This report suggests that some plant ncRNAs (e.g miRNAs and siRNAs) show higher stability as compared to other ncRNAs due to peculiar chemical characteristics (2'-O-methylation at 3' end). However, ingested or administered ncRNA must overcome many extracellular and cellular barriers to reach the intended target tissue or functional location in sufficient amount to exert any biological effect. Literature data indicate that chemically unmodified and unformulated ncRNAs exhibit very low stability in the gastrointestinal tract and in biological fluids and, in general, do not elicit major biological effects. This report also provides an overview of the RNA content in plant-derived foods and diets and discusses the controversies on the presence of dietary exogenous RNAs in the biological fluids of humans and animals and their effects. Finally, gaps in the scientific literature are highlighted and recommendations provided.

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Acute, subacute, and sub‐chronic toxicity evaluation of Bletilla formosana tubers in rats

Wang,

Zhang,

Zhao

et al. 2024

Food Safety and Health

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Bletilla formosana (Hayata) Schltr. is an important economic medicinal and edible plant in China. Its tubers (BFTs) are traditionally consumed as a beverage and canned foods for promoting human health. In this paper, the nutrients, the contents of total phenol, flavonoids, and polysaccharides, and the safety and toxicity of BFT are determined. The chemical analysis reported that BFT is rich in proteins, polysaccharides, polyphenols, flavonoids, and trace elements. The acute (14 days), subacute (28 days), and sub‐chronic (90 days) toxicities of BFT were evaluated for the first time in female and male rats. An acute toxicity study showed that the female rats by single oral administrations of BFT with 10,000 mg/kg body weight (BW) did not have behavioral changes and mortality, indicating that 50% lethal dose (LD50) of BFT was over 10,000 mg/kg BW. Similarly, BFT at 5000 mg/kg BW for consecutive 28 and 90 days in rats was also not toxic for rats after the analysis of physiological and biochemical parameters. Additionally, there are no significant differences on the histopathological changes of the heart, liver, spleen, lung, kidney, ovary, or testis between the control and BFT groups. Our findings revealed that BFT with concentration of less than 5000 mg/kg BW are safe for the female or male rats, indicating that BFT could be regarded as a safe food source.

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A 90-day toxicology study of high-amylose transgenic rice grain in Sprague–Dawley rats

Cited by 51 publications

References 35 publications

Toxicologic evaluation of chronic feeding of glyphosate-resistant transgenic soybean GTS40-3-2 meal to rats

Toxicologic evaluation of chronic feeding of glyphosate-resistant transgenic soybean GTS40-3-2 meal to rats

Literature review of baseline information on non‐coding RNA (ncRNA) to support the risk assessment of ncRNA‐based genetically modified plants for food and feed

Acute, subacute, and sub‐chronic toxicity evaluation of Bletilla formosana tubers in rats

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