A allele of ICAM-1 rs5498 and VCAM-1 rs3181092 is correlated with increased risk for periodontal disease

Abstract

ObjectivePeriodontal disease (PD) is viewed today as multifactorial problems initiated and sustained by bacteria but significantly modified by the body’s response to bacterial plaque. Recent studies have suggested that gene polymorphisms could be involved in the pathophysiology of periodontitis. This study aimed to investigate a possible correlation of the polymorphisms of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) with PD.MethodsThe genotypes of ICAM-1 and VCAM-1 were initially determined in PD patients using denaturing high performance liquid chromatography (DHPLC). ELISA was then conducted to measure ICAM-1 and VCAM-1 protein levels. Next, the association of ICAM-1/VCAM-1 genotype distribution and expression with clinical indicators and severity of PD was analyzed.ResultsPD patients contained increased levels of hemoglobin A1c (HbA1c), total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL), increased ICAM-1 and VCAM-1 protein levels, and decreased high-density lipoprotein (HDL) level. The GG genotype and G allele at ICAM-1 rs5498, as well as the AG and GG genotypes and G allele at VCAM-1 rs3181092 may reduce PD risk.ConclusionTo sum up, the overexpressed ICAM-1 and VCA M-1 as well as A allele of ICAM-1 rs5498 and VCAM-1 rs3181092 is associated with the onset of PD.

Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss

“…Remarkably increased information flow in gingival mutant cells included resistin, midkine (MK), vascular cell adhesion protein (VCAM), receptor activator of nuclear factor-kB ligand (RANKL), and sialic acid-binding Ig-like lectin 1 (SN) signaling ( Figure 4F ). Among them, resistin is a potential biomarker in periodontitis, 52 , 53 MK and VCAM are putative risk factors for periodontitis, 54 , 55 and RANKL drives inflammatory bone loss. 56 Remarkably increased information flow in synovial mutant cells included angiopoietin-like proteins (ANGPTL), lymphotoxin-a (LT), adiponectin, collagen, and IL-6 ( Figure S3E ).…”

Genetic Association of ICAM-1 (rs5498) Gene Polymorphism With Susceptibility to Stage II Grade B Periodontitis: A Case-Control Study in South Indian Population

“…However, according to the study’s findings, the ICAM-1 gene polymorphism and periodontitis did not appear to be significantly related. Similar to other chronic diseases, the pathophysiology of periodontitis is characterized by a number of cellular processes that ultimately result in the same clinical manifestation [ 22 ].…”

Neuroinflammation related to the blood–brain barrier and sphingosine‐1‐phosphate in a pre‐clinical model of periodontal diseases and depression in rats

“…In fact, single nucleotide polymorphisms (SNPs) affecting the synthesis of these molecules have been associated with a higher risk for periodontal diseases (Q. Sun et al, 2019).…”