A, B, H, and Lewis-a and Lewis-b blood group antigens in human breast cancer: Correlation with steroid hormone receptor and disease status

Idikio, Halliday; Manickavel, V.

doi:10.1007/bf01215930

Cited by 14 publications

(14 citation statements)

References 27 publications

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“…There have been only a few studies on the expression of Lewis B antigen in breast cancer tissue. (23) Idikio et al (23) suggested that loss of Le B in breast cancer increased with tumor grade, but did not correlate with axillary lymph node metastases. This is an important subject for future study because Le B is considered as an oncofetal tumor-associated antigen that is absent in normal breast tissue (24) and its expression may indicate a neoplastic process.…”

Section: Discussionmentioning

confidence: 98%

Breast Cancer Progression and Expression of Blood Group-Related Tumor-Associated Antigens

Stęplewska¹,

Plewska-Mazur²,

Gabriel³

et al. 2000

Hybridoma

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There is sufficient evidence that blood group related Lewis antigens are tumor-associated molecules. We have conducted immunohistochemical analysis of the expression of Lewis antigens in breast cancer tissue as an indicator of the degree of malignancy and as a prognostic factor. The studies were performed by examining 43 female patients diagnosed with invasive ductal carcinoma of the breast. Postoperative specimens were stained immunohistochemically using a panel of monoclonal antibodies (MAbs) specific for tumor-associated antigens: sialosyl LewisA, LewisA, LewisB, Lewisx, and LewisY. The aims of the study were to compare the appearance of metastases, degree of cancer stage (pTNM), and its histologic differentiation with the expression of Lewis phenotype. The evaluation of antigen expression was performed quantitatively and independently by two pathologists. Statistical significance was defined by Mann-Whitney test. The presented analysis of Lewis antigens showed higher expression of LeB and LeA (p = 0.03) in patients in stage N2 than in stage N1. The expression of LeB and LeY was higher in patients in stage T4 than in stage T1 (p = 0.02). No differences were observed for histologic differentiation. These data suggest that the expression of sialosyl-LeA and LeB antigens in breast cancer may predict metastases to lymph nodes.

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Section: Discussionmentioning

confidence: 98%

Breast Cancer Progression and Expression of Blood Group-Related Tumor-Associated Antigens

Stęplewska¹,

Plewska-Mazur²,

Gabriel³

et al. 2000

Hybridoma

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“…Like loss of ABO expression in tissue, [8][9][10][11] HER2/neu positivity is a result of altered glycosylation leading to HER2/neu expression. 12 Over-expression of HER2/neu cell membrane receptor protein in breast carcinoma is associated with tumor with the lack of correlation between blood type and HER2/ neu status noted in the present study.…”

Section: Discussionmentioning

confidence: 99%

Blood Type, Hormone Receptor Status, HER2/neu Status, and Survival in Breast Cancer: A Retrospective Study Exploring Relationships in a Phenotypically Well-Defined Cohort

Klimant

Glurich²,

Mukesh³

et al. 2011

Clinical Medicine & Research

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Purpose: Altered glycosylation has been associated with oncogenic potential. Relationships of blood types (where expression is due to glycosylation pattern) and HER2/neu (where expression arises due to altered glycosylation) and breast cancer-associated markers like estrogen receptor/progesterone receptor (ER/PR) were examined and related to outcomes in patients with breast cancer. Methods:A population-based retrospective study of 426 surgical breast cancer patients examined relationships between (1) patient characteristics, (2) breast tumor characteristics, and (3) outcomes of women diagnosed at the same medical center over a 10-year period relative to specific molecules defined by glycosylation patterns (eg. blood group, HER2/neu) and (4) ER/PR status. Results:Following stratification by blood group, subjects exhibited significant differences in tumor size with persons in blood groups A and B having greater numbers of tumors <2 cm and those with blood types AB and O having tumors >2 cm. After adjusting for age, disease stage, and treatment with trastuzumab, tamoxifen, or aromatase inhibitors, no significant differences were observed in 5-year overall and disease-free survival based on blood type grouping. Blood group B was over-represented among the breast cancer cohort compared to the reference population, while blood group AB was under-represented. Conclusion:No significant differences were observed in overall and disease-free survival based on blood group. No correlation was noted between HER2/neu, ER or PR status, and blood group type. Among this cohort, HER2/neu positivity was less than 20% and correlated with a 5-year disease-free survival rate >75% and overall survival of >80% across all blood groups.

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“…[13][14][15] Decreased levels of blood group antigens have been detected in breast carcinomas, and altered glycosylation and antigen expression has been implicated in the invasiveness of breast cancer, although the prognostic value of this is still uncertain. [15][16][17][18] Triple-negative breast cancer (TNBC), defined as the lack of expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) proteins, accounts for approximately 10-20 % of breast cancers. [19][20][21] TNBC has been associated with higher histological grade and larger tumor size at diagnosis, and patients generally have a shorter diseasefree interval and poorer overall survival.…”

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confidence: 99%

ABO Blood Type/Rh Factor and the Incidence and Outcomes for Patients with Triple-Negative Breast Cancer

Gao

Klimberg

et al. 2012

Ann Surg Oncol

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A, B, H, and Lewis-a and Lewis-b blood group antigens in human breast cancer: Correlation with steroid hormone receptor and disease status

Cited by 14 publications

References 27 publications

Breast Cancer Progression and Expression of Blood Group-Related Tumor-Associated Antigens

Breast Cancer Progression and Expression of Blood Group-Related Tumor-Associated Antigens

Blood Type, Hormone Receptor Status, HER2/neu Status, and Survival in Breast Cancer: A Retrospective Study Exploring Relationships in a Phenotypically Well-Defined Cohort

ABO Blood Type/Rh Factor and the Incidence and Outcomes for Patients with Triple-Negative Breast Cancer

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