2015
DOI: 10.2174/2352633501501010016
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A Basis of the Stomatocytoses of Erythrocytes by 1-Chloro-2, 4-Dinitrobenzene and Other Electrophilic Reagents

Abstract: On bases of previous observations on the band 3 anion exchange inhibition by the electrophilic reagent 1-fluoro-2,4-dinitrobenzene in resealed ghosts and a previously proposed band 3-based mechanism of control of the erythrocyte shape, it is suggested that stomatocytoses by 1-chloro-2,4-dinitrobenzene and other electrophilic reagents are due to an inhibition of the band 3 anion exchange by a covalent modification of Lys 539, one of the two lysine intramolecularly cross-linked by impermeant 4,4'-diisothiocyanod… Show more

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