2020
DOI: 10.1002/jrsm.1415
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A Bayesian approach to assessing small‐study effects in meta‐analysis of a binary outcome with controlled false positive rate

Abstract: Publication bias threatens meta‐analysis validity. It is often assessed via the funnel plot; an asymmetric plot implies small‐study effects, and publication bias is one cause of the asymmetry. Egger's regression test is a widely used tool to quantitatively assess such asymmetry. It examines the association between the observed effect sizes and their sample SEs; a strong association indicates small‐study effects. However, its false positive rates may be inflated if such an association intrinsically exists even … Show more

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Cited by 14 publications
(5 citation statements)
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“…A comprehensive summary of the different settings in these programs in the future would be useful. Third, it is difficult for the one‐stage methods to test for the potential publication bias 63 ; the conventional methods for publication bias depend on study‐specific effects and cannot be directly applied to the one‐stage framework.…”
Section: Discussionmentioning
confidence: 99%
“…A comprehensive summary of the different settings in these programs in the future would be useful. Third, it is difficult for the one‐stage methods to test for the potential publication bias 63 ; the conventional methods for publication bias depend on study‐specific effects and cannot be directly applied to the one‐stage framework.…”
Section: Discussionmentioning
confidence: 99%
“…The Egger test is a method used for detecting publication bias. It consists of a simple linear regression of the effect size across studies divided by the standard error versus the inverse of the standard error then testing (Palmer et al, 2008;L. Shi et al, 2020;X.…”
Section: Discussionmentioning
confidence: 99%
“…This research also detects publication bias with the Trim and Fill method. The method will remove outlier research, the smallest or the most extreme from the positive side of the funnel plot, and recalculate it so that the funnel plot is symmetrical L. Shi et al, 2020).…”
Section: Discussionmentioning
confidence: 99%
“…For example, the (log) OR's variance depends on the event counts, which are actually random variables instead of fixed variables. The (log) OR and variance are thus intrinsically associated, and such association could lead to non-negligible biases for small sample sizes and/or low even rates [82][83][84].…”
Section: Considering One-stage Methodsmentioning
confidence: 99%