A beginning of the end: new insights into the functional organization of telomeres

Wood, Ashley; Laster, Kyle Vaughn; Rice, Ellen L.; Kosak, Steven T.

doi:10.1080/19491034.2015.1048407

Cited by 41 publications

(46 citation statements)

References 45 publications

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“…This hybridization pattern resembles that pattern interpreted by Wood et al (2014Wood et al ( , 2015 as cytological evidence of the occurrence of t-loops formed between telomere and s-ITS. However, studies designed to search for s-ITSs in hylid karyotypes have not yet been performed, and the prevalence of ITSs in Hylidae remains an intriguing question to be assessed in further studies.…”

Section: Interstitial Telomeric Sequencessupporting

confidence: 84%

“…Several studies support the hypothesis that, in addition to possibly representing relics of chromosomal changes, the het-ITSs may themselves induce chromosome breakage and subsequent chromosomal rearrangements (reviewed in Ruiz-Herrera et al 2008 andBolzán 2012). Similarly, experimental and associative studies have also suggested the involvement of s-ITSs with genomic instability or chromosomal hot spots of recombination (Aksenova et al 2013, Wood et al 2015.…”

Section: Interstitial Telomeric Sequencesmentioning

confidence: 87%

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Comparative cytogenetics of tree frogs of the Dendropsophus marmoratus (Laurenti, 1768) group: conserved karyotypes and interstitial telomeric sequences

Lourenço¹,

Teixeira²,

Seger³

et al. 2016

CCG

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Section: Interstitial Telomeric Sequencessupporting

confidence: 84%

Section: Interstitial Telomeric Sequencesmentioning

confidence: 87%

Comparative cytogenetics of tree frogs of the Dendropsophus marmoratus (Laurenti, 1768) group: conserved karyotypes and interstitial telomeric sequences

Lourenço¹,

Teixeira²,

Seger³

et al. 2016

CCG

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“…Telomere capping protects the chromosomes against deterioration or endto-end fusion and prevents recognition by DNA damage pathways in response to genotoxic stress (1)(2)(3)(4), thus maintaining the genomic stability. A six-subunit protein assembly called the shelterin/telosome complex, which consists of telomere protection protein 1 (TPP1), i.e., ACD (adrenocortical dysplasia homolog)/shelterin component TPP1, telomere repeat factor (TRF) 1, TRF2, TRF1 interacting nuclear factor 2 (TIN2), repressor activator protein 1, and protection of telomere protein 1 (POT1), maintains telomere capping and integrity (3,5,6). Telomere shortening is the hallmark of aging.…”

mentioning

confidence: 99%

Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease

Ahmad

Sundar

Tormos

et al. 2017

Am J Respir Cell Mol Biol

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Lung cellular senescence and inflammatory response are the key events in the pathogenesis of chronic obstructive pulmonary disease (COPD) when cigarette smoke (CS) is the main etiological factor. Telomere dysfunction is induced by either critical shortening or disruption of the shelterin complex, leading to cellular senescence. However, it remains unknown whether disruption of the shelterin complex is responsible for CS-induced lung cellular senescence. Here we show that telomere protection protein 1 (TPP1) levels are reduced on telomeres in lungs from mice with emphysema, as well as in lungs from smokers and from patients with COPD. This is associated with persistent telomeric DNA damage, leading to cellular senescence. CS disrupts the interaction of TPP1 with the Sirtuin 1 (Sirt1) complex, leading to increased TPP1 acetylation and degradation. Lung fibroblasts deficient in Sirt1 or treated with a selective Sirt1 inhibitor exhibit increased cellular senescence and decreased TPP1 levels, whereas Sirt1 overexpression and pharmacological activation protect against CS-induced TPP1 reduction and telomeric DNA damage. Our findings support an essential role of TPP1 in protecting CS-induced telomeric DNA damage and cellular senescence, and therefore provide a rationale for a potential therapy for COPD, on the basis of the shelterin complex, in attenuating cellular senescence.

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“…Furthermore, ITSs may not appear in rearranged chromosomes, and this has been attributed to the molecular erosion of repetitive DNAs as well as to the protection of these ITSs (similar sequences to those present in the telomeres) by shelterin complexes from DNA damage that could not be detected by FISH [Mandrioli et al, 1999;Wood et al, 2015].…”

Section: Discussionmentioning

confidence: 99%

“…These telomeric sequences are associated with multiproteins that form the shelterin complex and protect chromosome ends against DNA damage or degradation while also allowing complete DNA replication and chromosome integrity [Simonet et al, 2011;Wood et al, 2015]. When telomeric sequences appear in different regions in chromosomes, such as in interstitial regions (interstitial telomeric sites, ITSs), these sequences have been related to evolutionary processes from an ancestral condition like fusions, inversions, and translocations at telomeres [Mandrioli et al, 1999;Wood et al, 2015].…”

mentioning

confidence: 99%

The Organization of Repetitive DNA in the Genomes of Amazonian Lizard Species in the Family Teiidae

Carvalho¹,

Pinheiro

Carmo³

et al. 2015

Cytogenet Genome Res

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Repetitive DNA is the largest fraction of the eukaryote genome and comprises tandem and dispersed sequences. It presents variations in relation to its composition, number of copies, distribution, dynamics, and genome organization, and participates in the evolutionary diversification of different vertebrate species. Repetitive sequences are usually located in the heterochromatin of centromeric and telomeric regions of chromosomes, contributing to chromosomal structures. Therefore, the aim of this study was to physically map repetitive DNA sequences (5S rDNA, telomeric sequences, tropomyosin gene 1, and retroelements Rex1 and SINE) of mitotic chromosomes of Amazonian species of teiids (Ameiva ameiva, Cnemidophorus sp. 1, Kentropyx calcarata, Kentropyx pelviceps, and Tupinambis teguixin) to understand their genome organization and karyotype evolution. The mapping of repetitive sequences revealed a distinct pattern in Cnemidophorus sp. 1, whereas the other species showed all sequences interspersed in the heterochromatic region. Physical mapping of the tropomyosin 1 gene was performed for the first time in lizards and showed that in addition to being functional, this gene has a structural function similar to the mapped repetitive elements as it is located preferentially in centromeric regions and termini of chromosomes.

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A beginning of the end: new insights into the functional organization of telomeres

Cited by 41 publications

References 45 publications

Comparative cytogenetics of tree frogs of the Dendropsophus marmoratus (Laurenti, 1768) group: conserved karyotypes and interstitial telomeric sequences

Comparative cytogenetics of tree frogs of the Dendropsophus marmoratus (Laurenti, 1768) group: conserved karyotypes and interstitial telomeric sequences

Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease

The Organization of Repetitive DNA in the Genomes of Amazonian Lizard Species in the Family Teiidae

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