A better method to measure total calcium in biological samples yields immediate payoffs

Manno, Carlo; Rı́os, Eduardo

doi:10.1085/jgp.201511370

Cited by 2 publications

(1 citation statement)

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“…For instance, reduced force production in aged muscle is partially caused by reduced Ca 2ϩ content and myofilament sensitivity (31). Our findings show that RANK mko denervated muscles have higher [CaT], which originates from increased intracellular Ca 2ϩ stocks (30,33). Therefore, higher Ca 2ϩ content potentially results in greater rates of Ca 2ϩ release, increased myoplasmic Ca 2ϩ transients, and, ultimately, preserved muscle force production.…”

Section: Discussionmentioning

confidence: 78%

Muscle RANK is a key regulator of Ca²⁺ storage, SERCA activity, and function of fast-twitch skeletal muscles

Dufresne

Dumont

Boulanger‐Piette

et al. 2016

American Journal of Physiology-Cell Physiology

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Receptor-activator of nuclear factor-κB (RANK), its ligand RANKL, and the soluble decoy receptor osteoprotegerin are the key regulators of osteoclast differentiation and bone remodeling. Here we show that RANK is also expressed in fully differentiated myotubes and skeletal muscle. Muscle RANK deletion has inotropic effects in denervated, but not in sham, extensor digitorum longus (EDL) muscles preventing the loss of maximum specific force while promoting muscle atrophy, fatigability, and increased proportion of fast-twitch fibers. In denervated EDL muscles, RANK deletion markedly increased stromal interaction molecule 1 content, a Ca(2+)sensor, and altered activity of the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) modulating Ca(2+)storage. Muscle RANK deletion had no significant effects on the sham or denervated slow-twitch soleus muscles. These data identify a novel role for RANK as a key regulator of Ca(2+)storage and SERCA activity, ultimately affecting denervated skeletal muscle function.

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Section: Discussionmentioning

confidence: 78%

Muscle RANK is a key regulator of Ca²⁺ storage, SERCA activity, and function of fast-twitch skeletal muscles

Dufresne

Dumont

Boulanger‐Piette

et al. 2016

American Journal of Physiology-Cell Physiology

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Sarco-Endoplasmic Reticulum Calcium Release Model Based on Changes in the Luminal Calcium Content

Guerrero‐Hernández

Sánchez-Vázquez

Martínez-Martínez

et al. 2019

Advances in Experimental Medicine and Biology

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A better method to measure total calcium in biological samples yields immediate payoffs

Cited by 2 publications

References 24 publications

Muscle RANK is a key regulator of Ca²⁺ storage, SERCA activity, and function of fast-twitch skeletal muscles

Muscle RANK is a key regulator of Ca²⁺ storage, SERCA activity, and function of fast-twitch skeletal muscles

Sarco-Endoplasmic Reticulum Calcium Release Model Based on Changes in the Luminal Calcium Content

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A better method to measure total calcium in biological samples yields immediate payoffs

Cited by 2 publications

References 24 publications

Muscle RANK is a key regulator of Ca2+ storage, SERCA activity, and function of fast-twitch skeletal muscles

Muscle RANK is a key regulator of Ca2+ storage, SERCA activity, and function of fast-twitch skeletal muscles

Sarco-Endoplasmic Reticulum Calcium Release Model Based on Changes in the Luminal Calcium Content

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Muscle RANK is a key regulator of Ca²⁺ storage, SERCA activity, and function of fast-twitch skeletal muscles

Muscle RANK is a key regulator of Ca²⁺ storage, SERCA activity, and function of fast-twitch skeletal muscles