A bi-directional immune network mechanism: Simultaneous induction of idiotype and anti-anti-idiotype in rabbits immunized with antibody to a common idiotypic specificity of anti-VHa2-allotype antibodies

Kazdin, Dori S.; Horng, Wayne J.

doi:10.1016/0161-5890(83)90078-0

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Rabbit Internal Images Of Allotopes Of the B Series1

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1983

1993

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Cited by 8 publications

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“…The same results were obtained in the rabbit anti-a2 system (Kazdin & Homg 1983). A fraction of the Ab3 antibodies against anti-(anti-a2) antibodies precipitated a2 IgG, another fraction did not react with the antigen.…”

Section: Rabbit Internal Images Of Allotopes Of the B Seriessupporting

confidence: 78%

Internal Images of Rabbit Immunoglobulin Allotopes

Cazenave

Roland

1984

Immunological Reviews

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Section: Rabbit Internal Images Of Allotopes Of the B Seriessupporting

confidence: 78%

Internal Images of Rabbit Immunoglobulin Allotopes

Cazenave

Roland

1984

Immunological Reviews

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The human immune response against major allergens from house dust mite, Dermatophagoides pteronyssinus: II. Idiotypic cross‐reactions of allergen‐specific antibodies

et al. 1986

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Antisera were prepared in rabbits against the idiotypic (Id) determinants of antiallergen antibodies. These antibodies were isolated from the plasma of 10 unrelated patients by immunoabsorption. Three major allergens isolated from the house dust mite, Dermatophagoides pteronyssinus (DPT), were used. The anti-Id antisera were rendered specific by successive absorption on insolubilized allergens, IgG and IgM from a pool of human sera and Ig from the donor after removal of anti-DPT antibodies by absorption. Anti-Id antibodies raised essentially against IgG antibodies were found to inhibit the agglutinating activity of both IgG and IgM anti-DPT antibodies toward allergen-coated latex. These anti-Id antibodies were also able to inhibit partly the binding of radiolabeled allergen to IgE anti-DPT antibodies. Matching the anti-Id antisera with the various individual anti-DPT antibodies revealed an Id cross-reactivity of about 71% for IgG, 61% for IgM and 62% for IgE. A second and predominant type of anti-Id antibodies recognized bystander idiotopes as the allergen did not inhibit Id-anti-Id reaction. These idiotopes were apparently more specific to individuals (private) as the anti-DPT antibodies of a given patient did not agglutinate latex particles coated with anti-Id antibodies prepared against Id of another patient.

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Recent Research on Genetic Regulation and Function of Some Serum Proteins

Grubb

1986

Advances in Forensic Haemogenetics

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A bi-directional immune network mechanism: Simultaneous induction of idiotype and anti-anti-idiotype in rabbits immunized with antibody to a common idiotypic specificity of anti-VHa2-allotype antibodies

Cited by 8 publications

References 25 publications

Internal Images of Rabbit Immunoglobulin Allotopes

Internal Images of Rabbit Immunoglobulin Allotopes

The human immune response against major allergens from house dust mite, Dermatophagoides pteronyssinus: II. Idiotypic cross‐reactions of allergen‐specific antibodies

Recent Research on Genetic Regulation and Function of Some Serum Proteins

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