A bi-layered asymmetric membrane loaded with demineralized dentin matrix for guided bone regeneration

A novel bi-layered asymmetric membrane incorporating demineralized dentin matrix accelerates tissue healing and bone regeneration in a rat skull defect model

“…The effective cellular barrier function of the DPP bilayer membrane had been proved in our previous study. 35 Combined with the current results, it is reasonable to conclude that the DPP bilayer membrane exhibits barrier/osteoinduction dual functions in bone defect areas. Compared with the traditional barrier membrane, the superior osteogenic activity endowed the DPP bilayer membrane with more advantages in GBR applications.…”

“…In order to verify the osteogenic effects of DPP bilayer membranes in vivo , a rat skull CSD model was constructed. Based on in vitro experimental results, 35 the 20% DPP bilayer membrane with the best osteogenic activity was selected as the representative to be tested in the experimental group. The rats in the blank control group did not receive any treatment after modelling.…”