A bibliometric analysis of research on (R)-ketamine from 2002 to 2021

He, Teng; Wang, Di; Wu, Zifeng; Huang, Ching-Hui; Xu, Xiangyang; Xu, Xinping; Liu, Cunming; Hashimoto, Kenji; Yang, Chun

doi:10.1016/j.neuropharm.2022.109207

Cited by 28 publications

(14 citation statements)

References 36 publications

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“…Furthermore, there is evidence that arketamine can ameliorate cognitive deficits in offspring after MIA through activation of BDNF-TrkB signaling [ 122 ]. Preclinical findings suggest that BDNF-TrkB signaling could play a role in the beneficial effects of arketamine in several animal models [ 36 , 42 – 45 , 66 , 143 – 147 ]. However, the precise molecular and cellular mechanisms underlying the beneficial effects of arketamine remain elusive [ 36 , 42 – 46 , 148 ].…”

Section: Discussionmentioning

confidence: 99%

Arketamine for cognitive impairment in psychiatric disorders

Hashimoto

2023

Eur Arch Psychiatry Clin Neurosci

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Cognitive impairment has been observed in patients with various psychiatric disorders, including schizophrenia, major depressive disorder (MDD), and bipolar disorder (BD). Although modern therapeutic drugs can improve certain symptoms (i.e., psychosis, depression) in these patients, these drugs have not been found to improve cognitive impairment. The N-methyl-D-aspartate receptor antagonist (R,S)-ketamine has attracted attention as a rapidly acting antidepressant. In addition to its robust antidepressant effects, (R,S)-ketamine has been suggested to improve cognitive impairment in patients with MDD and BD, despite causing cognitive impairment in healthy control subjects. (R,S)-ketamine is a racemic mixture of equal amounts of (R)-ketamine (or arketamine) and (S)-ketamine (or esketamine). Arketamine has been found to have more potent antidepressant-like actions than esketamine in rodents. Interestingly, arketamine, but not esketamine, has been suggested to improve phencyclidine-induced cognitive deficits in mice. Furthermore, arketamine has been suggested to ameliorate cognitive deficits in rodent offspring after maternal immune activation. In the current article, it is proposed that arketamine has therapeutic potential for treating cognitive impairment in patients with psychiatric disorders. Additionally, the potential role of the gut–microbiome–brain axis in cognitive impairment in psychiatric disorders is discussed.

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Section: Discussionmentioning

confidence: 99%

Arketamine for cognitive impairment in psychiatric disorders

Hashimoto

2023

Eur Arch Psychiatry Clin Neurosci

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“…During the set search period, a total of 24,890 authors were involved in the study of the topic. According to Price Law [ 41 ], the authors who have published six or more in the topic were core authors. The top 15 authors in terms of publications are shown in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

A Bibliometric Analysis of Research on the Role of BDNF in Depression and Treatment

Zhang

et al. 2022

Biomolecules

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Brain-derived neurotrophic factor (BDNF), as the most widely distributed and widely studied neurotrophic factor in the mammalian brain, plays a key role in depression and the mechanisms of action for antidepressants. Currently, there is a large number of studies on the role of BDNF in the pathogenesis and therapeutic mechanism of depression. The quantity and quality of these studies, however, are unknown. To give beginners a quicker introduction to this research topic, we therefore performed a bibliometric analysis. A total of 5300 publications were included. We obtained the publications on this topic from the Web of Science database, and a variety of bibliographic elements were collected, including annual publications, authors, countries/regions, institutions, journals, and keywords. Moreover, we found that oxidative stress and neuroinflammation are the hotspots in the field in very recent years. Collectively, this study provides a comprehensive summary and analysis on the role of BDNF in depression and its treatment and offers meaningful values for beginners on this topic.

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“…Web of Science, as a high-quality digital literature resource database, is considered the most suitable database for bibliometric analysis due to its powerful functions ( He et al, 2022 ). We searched all publications related to emergence delirium from the Scientific Network Core collection database of Clarivate analysis, including versions of SCI-EXPANDED (2003-present), SSCI (2003-present), AHCI (2003-present), ESCI (2017-present), CCR-Expanded (1985-present), and IC (1993-present).…”

Section: Methodsmentioning

confidence: 99%

Global trends in research related to emergence delirium, 2012–2021: A bibliometric analysis

Wang

Cai

et al. 2023

Front. Psychol.

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IntroductionEmergence delirium is a kind of mental disorder during the early awakening period after general anesthesia, which is manifested as the combination of perceptual disturbance and psychomotor agitation. It is an independent risk factor for postoperative delirium and even long-term postoperative cognitive decline, which often affects the postoperative outcome and deserves the attention of clinical anesthesiologists. There are many studies on emergence delirium, but the quantity and quality of these studies are unclear. Therefore, we conducted a bibliometric analysis of studies on emergence delirium between January 2012 and December 2021. Through the analysis of relevant literature, the research hotspots and trends of emergence delirium are understood, which can provide a reference for future research.MethodsWe searched the Web of Science Core Collection (WoSCC) for original articles and reviews related to emergence delirium published between 2012 and 2021, and collected a variety of bibliographic elements, including annual publications, authors, countries/regions, institutions, journals, and keywords. Three different science-based tools (CiteSpace, VOSviewer and Bibliometrix) were used for this comprehensive analysis.ResultsFrom January 2012 to December 2021, a total of 912 emergence delirium (ED) related literature were published, including 766 original research articles and 146 review articles. The number of publications has increased every year except 2016. The United States published 203 articles, ranking first with China, followed by South Korea (95 articles). The United States is also the country with the most citations (4,508), and Yonsei Univ is the most productive institution. The most published journal was PEDIATRIC ANESTHESIA, with the highest h and g index. LEE JH is the most influential author in this field.Discussion“Children, emergence agitation, delirium, dexmedetomidine” are the hot topics in this field in recent years. The bibliometric analysis in this field will provide the future direction for the study of emergence delirium for clinicians.

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A bibliometric analysis of research on (R)-ketamine from 2002 to 2021

Cited by 28 publications

References 36 publications

Arketamine for cognitive impairment in psychiatric disorders

Arketamine for cognitive impairment in psychiatric disorders

A Bibliometric Analysis of Research on the Role of BDNF in Depression and Treatment

Global trends in research related to emergence delirium, 2012–2021: A bibliometric analysis

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