A bibliometric analysis of research hotspots and cutting-edge trends in cardiovascular disease biomarkers

Abstract

Background Biomarkers have increasingly played a significant role in the diagnosis, prognosis, and risk assessment of cardiovascular diseases (CVDs) in recent years. Nonetheless, a comprehensive and systematic organization evaluating cardiovascular biomarkers within the existing literature has been notably absent. Methods Gathering relevant literature on cardiovascular biomarkers from the Web of Science Core Collection, followed by scientific bibliometric analyses using VOSviewer, CiteSpace, and bibliometrix to explore the spatiotemporal distribution, top authors, countries, references, keywords, research hotspots, and trends in the literature. Results Furnishing fundamental insights into research in this domain, indicating a progressive surge in related studies. CVD biomarkers linked to blood have been identified in urine, saliva, and sweat. Research hotspots that garner significant attention in this field include inflammation levels, immune modulation, cardiac stress, coagulation function, endothelial dysfunction, lipid status, oxidative stress, matrix remodeling, DNA methylation, and micrornas. Epigenetics and genomics are currently experiencing a burgeoning phase of research activity. Conclusion Many CVD biomarkers found in the blood can also be detected in other body fluids. Furthermore, there are specific CVD biomarkers present in different body fluids. Therefore, utilizing non-invasive testing methods for collecting patient's non-blood body fluids has been proven to be a reliable approach for predicting, diagnosing, and assessing prognosis.